Adicet Bio [ACET] vs Orchestra BioMed [OBIO] Detailed Stock Comparison

Adicet Bio, Inc.

NASDAQ
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Orchestra BioMed Holdings, Inc.

NASDAQ
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TLDR: Quick Comparison Summary

Based on 20 vital metrics comparison: Adicet Bio, Inc. wins in 6 metrics, Orchestra BioMed Holdings, Inc. wins in 9 metrics, with 0 ties. Orchestra BioMed Holdings, Inc. appears stronger overall.

View Metrics Details

Vital Metrics Comparison

Metric Adicet Bio, Inc. Orchestra BioMed Holdings, Inc. Better
P/E Ratio (TTM) -0.47 N/A N/A
Price-to-Book Ratio 0.54 4.48 Adicet Bio, Inc.
Debt-to-Equity Ratio 9.26 25.17 Adicet Bio, Inc.
PEG Ratio 0.01 -2.47 Adicet Bio, Inc.
EV/EBITDA 0.49 -3.22 Adicet Bio, Inc.
Profit Margin (TTM) 0.00% -157.40% Adicet Bio, Inc.
Operating Margin (TTM) 0.00% 21.85% Orchestra BioMed Holdings, Inc.
EBITDA Margin (TTM) N/A 21.85% N/A
Return on Equity -67.55% -109.41% Adicet Bio, Inc.
Return on Assets (TTM) -37.00% -33.90% Orchestra BioMed Holdings, Inc.
Free Cash Flow (TTM) $-96.98M $-49.45M Orchestra BioMed Holdings, Inc.
1-Year Return -32.92% 32.69% Orchestra BioMed Holdings, Inc.
Price-to-Sales Ratio (TTM) N/A 7.36 N/A
Enterprise Value $-57.15M $165.62M Orchestra BioMed Holdings, Inc.
EV/Revenue Ratio N/A 4.95 N/A
Gross Profit Margin (TTM) N/A 99.84% N/A
Revenue per Share (TTM) $0 $1 Orchestra BioMed Holdings, Inc.
Earnings per Share (Diluted) $-16.95 $-1.11 Orchestra BioMed Holdings, Inc.
Beta (Stock Volatility) 1.58 0.60 Orchestra BioMed Holdings, Inc.
Short % of Float 8.14% 2.46% Orchestra BioMed Holdings, Inc.

Adicet Bio, Inc. vs Orchestra BioMed Holdings, Inc. Stock Performance Analysis

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ACET
OBIO

Performance Comparison

Short-term Returns

Stock1D1W1M3M6MYTD
Adicet Bio, Inc.-1.22%-8.04%-0.37%-1.22%2.78%-7.94%
Orchestra BioMed Holdings, Inc.-3.17%0.51%6.72%-12.75%-7.67%-7.89%

Long-term Returns

Stock1Y3Y5Y10Y15Y20Y
Adicet Bio, Inc.-32.92%-88.57%-95.23%-99.57%-99.57%-99.57%
Orchestra BioMed Holdings, Inc.32.69%-55.09%-60.58%-49.38%-49.38%-49.38%

Performance & Financial Health Analysis: Adicet Bio, Inc. vs Orchestra BioMed Holdings, Inc.

MetricACETOBIO
Market Information
Market Cap i$75.84M$242.86M
Market Cap CategoryMicro capMicro cap
10 Day Avg. Volume i209,881133,035
90 Day Avg. Volume i147,564183,128
Last Close$8.12$3.97
52 Week Range$6.01 - $17.44$2.20 - $5.42
% from 52W High-53.44%-26.81%
All-Time High$147.68 (Feb 26, 2018)$23.39 (Apr 03, 2023)
% from All-Time High-94.50%-83.03%
Growth Metrics
Quarterly Revenue GrowthN/A121.20%
Quarterly Earnings GrowthN/A121.20%
Financial Health
Profit Margin (TTM) i0.00%-1.57%
Operating Margin (TTM) i0.00%0.22%
Return on Equity (TTM) i-0.68%-1.09%
Debt to Equity (MRQ) i9.2625.17
Cash & Liquidity
Book Value per Share (MRQ)$14.83$0.94
Cash per Share (MRQ)$14.75$1.82
Operating Cash Flow (TTM) i$-95,246,000$-48,963,000
Levered Free Cash Flow (TTM) i$-53,868,752$-20,247,876
Dividends
Last 12-Month Dividend Yield iN/AN/A
Last 12-Month Dividend iN/AN/A

Valuation & Enterprise Metrics Analysis: Adicet Bio, Inc. vs Orchestra BioMed Holdings, Inc.

MetricACET (Apr 24, 2026)OBIO (Apr 24, 2026)
Price Ratios
P/E Ratio (TTM) i-0.47N/A
Forward P/E i-2.40-2.47
PEG Ratio i0.01-2.47
Price to Sales (TTM) iN/A7.36
Price to Book (MRQ) i0.544.48
Market Capitalization
Market Capitalization i$75.84M$242.86M
Enterprise Value i$-57,153,124$165.62M
Enterprise Value Metrics
Enterprise to Revenue iN/A4.95
Enterprise to EBITDA i0.49-3.22
Risk & Other Metrics
Beta i1.580.60
Book Value per Share (MRQ) i$14.83$0.94

Financial Statements Comparison: Adicet Bio, Inc. vs Orchestra BioMed Holdings, Inc.

Financial Metrics

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Revenue

Operating Margin

Profit Margin

Long Term Debt

Income Flow Analysis

Financial Statements Comparison

Income Statement

MetricACET (2025)OBIO (2025)
Revenue/Sales i033.48M
Cost of Goods Sold iN/A190,000
COGS % of Revenue i-0.6%
Gross Profit iN/A33.29M
Gross Margin i-99.4%
Research & Development i99.13M58.19M
Operating Income (EBIT) i-122.11M-51.81M
Operating Margin i--154.7%
EBITDA i-110.39M-51.48M
EBITDA Margin i--153.8%
Pre-Tax Income i-116.80M-52.70M
Pre-Tax Income % of Revenue i--157.4%
Income Tax i0N/A
Income Tax % of Revenue i-0.0%
Net Income (Profit) i-116.80M-52.70M
Profit Margin i--157.4%

Balance Sheet & Liquidity Metrics

MetricACET (2025)OBIO (2025)
Cash & Equivalents i38.92M34.69M
Total Current Assets i160.93M107.91M
Total Current Assets % of Revenue i-322.3%
Total Current Liabilities i21.53M16.74M
Total Current Liabilities % of Revenue i-50.0%
Long-Term Debt i11.55M15.20M
Long-Term Debt % of Revenue i-45.4%
Total Shareholders Equity i159.21M53.57M
Retained Earnings i-614.70M-362.58M
Retained Earnings % of Revenue i--1,082.9%
Property, Plant & Equipment i25.67M4.24M

Cash Flow Statement Comparison

MetricACET (2025)OBIO (2025)
Operating Cash Flow i-94.84M-54.46M
Operating Cash Flow % of Revenue i--162.6%
Capital Expenditures i-1.74M-489,000
Free Cash Flow i-96.98M-49.45M
FCF Margin i--147.7%
Debt Repayment i-150,000N/A
Common Stock Repurchase iN/AN/A

Short Interest & Institutional Ownership Analysis

MetricACETOBIO
Shares Short i656,546957,939
Short Ratio i5.933.91
Short % of Float i8.14%2.46%
Shares Outstanding i9.59M57.03M
Float Shares i6.80M32.49M
% Held by Insiders i0.90%27.92%
% Held by Institutions i72.52%38.23%
% Held by Public i26.58%33.85%

Dividend Analysis & Yield Comparison: Adicet Bio, Inc. vs Orchestra BioMed Holdings, Inc.

MetricACETOBIO
Last 12-Month Dividend iN/AN/A
Last 12-Month Dividend Yield iN/AN/A
3-Year Avg Annual Dividend iN/AN/A
3-Year Avg Dividend Yield iN/AN/A
3-Year Total Dividends iN/AN/A
Ex-Dividend DateN/AN/A