Guardant Health [GH] vs Thermo Fisher [TMO] Detailed Stock Comparison

Guardant Health Inc.

NASDAQ
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Thermo Fisher Scientific Inc.

NYSE
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TLDR: Quick Comparison Summary

Based on 21 vital metrics comparison: Guardant Health Inc. wins in 2 metrics, Thermo Fisher Scientific Inc. wins in 16 metrics, with 0 ties. Thermo Fisher Scientific Inc. appears stronger overall.

View Metrics Details

Vital Metrics Comparison

Metric Guardant Health Inc. Thermo Fisher Scientific Inc. Better
P/E Ratio (TTM) -26.47 25.84 Thermo Fisher Scientific Inc.
Price-to-Book Ratio -113.87 3.31 Thermo Fisher Scientific Inc.
Debt-to-Equity Ratio -17.22 82.91 Thermo Fisher Scientific Inc.
PEG Ratio -2.38 2.29 Thermo Fisher Scientific Inc.
EV/EBITDA -31.17 19.02 Thermo Fisher Scientific Inc.
Profit Margin (TTM) -42.39% 15.15% Thermo Fisher Scientific Inc.
Operating Margin (TTM) -42.91% 17.89% Thermo Fisher Scientific Inc.
EBITDA Margin (TTM) N/A 17.89% N/A
Return on Equity 419.18% 13.52% Guardant Health Inc.
Return on Assets (TTM) -15.59% 5.00% Thermo Fisher Scientific Inc.
Free Cash Flow (TTM) $-233.07M $6.29B Thermo Fisher Scientific Inc.
Dividend Yield N/A 0.38% N/A
1-Year Return 167.03% 16.53% Guardant Health Inc.
Price-to-Sales Ratio (TTM) 12.07 3.86 Thermo Fisher Scientific Inc.
Enterprise Value $12.36B $214.76B Thermo Fisher Scientific Inc.
EV/Revenue Ratio 12.59 4.75 Thermo Fisher Scientific Inc.
Gross Profit Margin (TTM) 64.63% N/A N/A
Revenue per Share (TTM) $8 $120 Thermo Fisher Scientific Inc.
Earnings per Share (Diluted) $-3.32 $18.18 Thermo Fisher Scientific Inc.
Beta (Stock Volatility) 1.65 0.97 Thermo Fisher Scientific Inc.
Short % of Float 10.93% 1.22% Thermo Fisher Scientific Inc.

Guardant Health Inc. vs Thermo Fisher Scientific Inc. Stock Performance Analysis

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GH
TMO

Performance Comparison

Short-term Returns

Stock1D1W1M3M6MYTD
Guardant Health Inc.-1.37%3.95%36.77%48.91%26.44%27.60%
Thermo Fisher Scientific Inc.0.93%0.87%8.07%0.79%-17.74%-20.05%

Long-term Returns

Stock1Y3Y5Y10Y15Y20Y
Guardant Health Inc.167.03%254.87%9.50%350.75%350.75%350.75%
Thermo Fisher Scientific Inc.16.53%-12.65%-2.72%220.94%654.32%1,231.84%

Performance & Financial Health Analysis: Guardant Health Inc. vs Thermo Fisher Scientific Inc.

MetricGHTMO
Market Information
Market Cap i$11.53B$174.55B
Market Cap CategoryLarge capLarge cap
10 Day Avg. Volume i2,518,2322,356,220
90 Day Avg. Volume i2,085,5572,071,517
Last Close$129.82$473.72
52 Week Range$40.35 - $135.00$385.46 - $643.99
% from 52W High-3.84%-26.44%
All-Time High$181.07 (Feb 08, 2021)$672.34 (Dec 27, 2021)
% from All-Time High-28.30%-29.54%
Growth Metrics
Quarterly Revenue Growth0.39%0.06%
Quarterly Earnings Growth0.39%0.10%
Financial Health
Profit Margin (TTM) i-0.42%0.15%
Operating Margin (TTM) i-0.43%0.18%
Return on Equity (TTM) i4.19%0.14%
Debt to Equity (MRQ) i-17.2282.91
Cash & Liquidity
Book Value per Share (MRQ)$-0.76$141.96
Cash per Share (MRQ)$9.16$8.75
Operating Cash Flow (TTM) i$-184,760,000$8.29B
Levered Free Cash Flow (TTM) i$-88,105,872$5.51B
Dividends
Last 12-Month Dividend Yield iN/A0.38%
Last 12-Month Dividend iN/A$1.76

Valuation & Enterprise Metrics Analysis: Guardant Health Inc. vs Thermo Fisher Scientific Inc.

MetricGH (Apr 24, 2026)TMO (Apr 26, 2026)
Price Ratios
P/E Ratio (TTM) i-26.4725.84
Forward P/E i-129.0817.16
PEG Ratio i-2.382.29
Price to Sales (TTM) i12.073.86
Price to Book (MRQ) i-113.873.31
Market Capitalization
Market Capitalization i$11.53B$174.55B
Enterprise Value i$12.36B$214.76B
Enterprise Value Metrics
Enterprise to Revenue i12.594.75
Enterprise to EBITDA i-31.1719.02
Risk & Other Metrics
Beta i1.650.97
Book Value per Share (MRQ) i$-0.76$141.96

Financial Statements Comparison: Guardant Health Inc. vs Thermo Fisher Scientific Inc.

Financial Metrics

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Revenue

Operating Margin

Profit Margin

Long Term Debt

Income Flow Analysis

Financial Statements Comparison

Income Statement

MetricGH (2025)TMO (2025)
Revenue/Sales i982.02M44.56B
Cost of Goods Sold i349.01M26.32B
COGS % of Revenue i35.5%59.1%
Gross Profit i633.01M18.24B
Gross Margin i64.5%40.9%
Research & Development i364.19M1.40B
Operating Income (EBIT) i-437.25M8.11B
Operating Margin i-44.5%18.2%
EBITDA i-373.91M11.86B
EBITDA Margin i-38.1%26.6%
Pre-Tax Income i-417.54M7.31B
Pre-Tax Income % of Revenue i-42.5%16.4%
Income Tax i-1.26M547.00M
Income Tax % of Revenue i-0.1%1.2%
Net Income (Profit) i-416.28M6.72B
Profit Margin i-42.4%15.1%

Balance Sheet & Liquidity Metrics

MetricGH (2025)TMO (2025)
Cash & Equivalents i378.20M9.85B
Total Current Assets i1.47B28.71B
Total Current Assets % of Revenue i149.3%64.4%
Total Current Liabilities i302.73M15.19B
Total Current Liabilities % of Revenue i30.8%34.1%
Long-Term Debt i1.68B35.85B
Long-Term Debt % of Revenue i171.3%80.5%
Total Shareholders Equity i-99.31M53.54B
Retained Earnings i-2.99B59.16B
Retained Earnings % of Revenue i-304.9%132.8%
Property, Plant & Equipment i158.85M0

Cash Flow Statement Comparison

MetricGH (2025)TMO (2025)
Operating Cash Flow i-230.19M7.82B
Operating Cash Flow % of Revenue i-23.4%17.5%
Capital Expenditures i-48.31M-1.48B
Free Cash Flow i-233.07M6.29B
FCF Margin i-23.7%14.1%
Debt Repayment iN/A-3.51B
Common Stock Repurchase i-45.01M-3.00B

Short Interest & Institutional Ownership Analysis

MetricGHTMO
Shares Short i13.70M4.54M
Short Ratio i7.502.38
Short % of Float i10.93%1.22%
Shares Outstanding i130.64M371.62M
Float Shares i125.75M371.07M
% Held by Insiders i4.04%0.17%
% Held by Institutions i101.22%95.23%
% Held by Public i-5.26%4.60%

Dividend Analysis & Yield Comparison: Guardant Health Inc. vs Thermo Fisher Scientific Inc.

MetricGHTMO
Last 12-Month Dividend iN/A$1.76
Last 12-Month Dividend Yield iN/A0.38%
3-Year Avg Annual Dividend iN/A$1.60
3-Year Avg Dividend Yield iN/A0.08%
3-Year Total Dividends iN/A$4.80
Ex-Dividend DateN/AMar 13, 2026