Illumina [ILMN] vs Thermo Fisher [TMO] Detailed Stock Comparison

Illumina, Inc.

NASDAQ
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Thermo Fisher Scientific Inc.

NYSE
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TLDR: Quick Comparison Summary

Based on 21 vital metrics comparison: Illumina, Inc. wins in 9 metrics, Thermo Fisher Scientific Inc. wins in 10 metrics, with 0 ties. Thermo Fisher Scientific Inc. appears stronger overall.

View Metrics Details

Vital Metrics Comparison

Metric Illumina, Inc. Thermo Fisher Scientific Inc. Better
P/E Ratio (TTM) 24.22 25.84 Illumina, Inc.
Price-to-Book Ratio 7.42 3.31 Thermo Fisher Scientific Inc.
Debt-to-Equity Ratio 93.76 82.91 Thermo Fisher Scientific Inc.
PEG Ratio 0.28 2.29 Illumina, Inc.
EV/EBITDA 18.53 19.02 Illumina, Inc.
Profit Margin (TTM) 19.57% 15.15% Illumina, Inc.
Operating Margin (TTM) 19.67% 17.89% Illumina, Inc.
EBITDA Margin (TTM) 19.67% 17.89% Illumina, Inc.
Return on Equity 33.36% 13.52% Illumina, Inc.
Return on Assets (TTM) 8.39% 5.00% Illumina, Inc.
Free Cash Flow (TTM) $931.00M $6.29B Thermo Fisher Scientific Inc.
Dividend Yield N/A 0.38% N/A
1-Year Return 85.17% 16.53% Illumina, Inc.
Price-to-Sales Ratio (TTM) 4.65 3.86 Thermo Fisher Scientific Inc.
Enterprise Value $21.10B $214.76B Thermo Fisher Scientific Inc.
EV/Revenue Ratio 4.86 4.75 Thermo Fisher Scientific Inc.
Gross Profit Margin (TTM) 65.49% N/A N/A
Revenue per Share (TTM) $28 $120 Thermo Fisher Scientific Inc.
Earnings per Share (Diluted) $5.45 $18.18 Thermo Fisher Scientific Inc.
Beta (Stock Volatility) 1.49 0.97 Thermo Fisher Scientific Inc.
Short % of Float 7.46% 1.22% Thermo Fisher Scientific Inc.

Illumina, Inc. vs Thermo Fisher Scientific Inc. Stock Performance Analysis

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ILMN
TMO

Performance Comparison

Short-term Returns

Stock1D1W1M3M6MYTD
Illumina, Inc.3.68%5.60%17.08%39.91%23.70%24.22%
Thermo Fisher Scientific Inc.0.93%0.87%8.07%0.79%-17.74%-20.05%

Long-term Returns

Stock1Y3Y5Y10Y15Y20Y
Illumina, Inc.85.17%-19.62%-63.72%20.74%125.39%1,163.50%
Thermo Fisher Scientific Inc.16.53%-12.65%-2.72%220.94%654.32%1,231.84%

Performance & Financial Health Analysis: Illumina, Inc. vs Thermo Fisher Scientific Inc.

MetricILMNTMO
Market Information
Market Cap i$19.18B$174.55B
Market Cap CategoryLarge capLarge cap
10 Day Avg. Volume i1,531,4652,356,220
90 Day Avg. Volume i1,454,4722,071,517
Last Close$166.89$473.72
52 Week Range$86.03 - $177.22$385.46 - $643.99
% from 52W High-5.83%-26.44%
All-Time High$540.63 (Feb 08, 2021)$672.34 (Dec 27, 2021)
% from All-Time High-69.13%-29.54%
Growth Metrics
Quarterly Revenue Growth0.05%0.06%
Quarterly Earnings Growth0.79%0.10%
Financial Health
Profit Margin (TTM) i0.20%0.15%
Operating Margin (TTM) i0.20%0.18%
Return on Equity (TTM) i0.33%0.14%
Debt to Equity (MRQ) i93.7682.91
Cash & Liquidity
Book Value per Share (MRQ)$17.80$141.96
Cash per Share (MRQ)$10.68$8.75
Operating Cash Flow (TTM) i$1.08B$8.29B
Levered Free Cash Flow (TTM) i$786.00M$5.51B
Dividends
Last 12-Month Dividend Yield iN/A0.38%
Last 12-Month Dividend iN/A$1.76

Valuation & Enterprise Metrics Analysis: Illumina, Inc. vs Thermo Fisher Scientific Inc.

MetricILMN (Apr 24, 2026)TMO (Apr 26, 2026)
Price Ratios
P/E Ratio (TTM) i24.2225.84
Forward P/E i22.6617.16
PEG Ratio i0.282.29
Price to Sales (TTM) i4.653.86
Price to Book (MRQ) i7.423.31
Market Capitalization
Market Capitalization i$19.18B$174.55B
Enterprise Value i$21.10B$214.76B
Enterprise Value Metrics
Enterprise to Revenue i4.864.75
Enterprise to EBITDA i18.5319.02
Risk & Other Metrics
Beta i1.490.97
Book Value per Share (MRQ) i$17.80$141.96

Financial Statements Comparison: Illumina, Inc. vs Thermo Fisher Scientific Inc.

Financial Metrics

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Revenue

Operating Margin

Profit Margin

Long Term Debt

Income Flow Analysis

Financial Statements Comparison

Income Statement

MetricILMN (2025)TMO (2025)
Revenue/Sales i4.34B44.56B
Cost of Goods Sold i1.47B26.32B
COGS % of Revenue i33.9%59.1%
Gross Profit i2.87B18.24B
Gross Margin i66.1%40.9%
Research & Development i967.00M1.40B
Operating Income (EBIT) i817.00M8.11B
Operating Margin i18.8%18.2%
EBITDA i1.47B11.86B
EBITDA Margin i33.8%26.6%
Pre-Tax Income i1.09B7.31B
Pre-Tax Income % of Revenue i25.0%16.4%
Income Tax i236.00M547.00M
Income Tax % of Revenue i5.4%1.2%
Net Income (Profit) i850.00M6.72B
Profit Margin i19.6%15.1%

Balance Sheet & Liquidity Metrics

MetricILMN (2025)TMO (2025)
Cash & Equivalents i1.42B9.85B
Total Current Assets i3.29B28.71B
Total Current Assets % of Revenue i75.7%64.4%
Total Current Liabilities i1.59B15.19B
Total Current Liabilities % of Revenue i36.5%34.1%
Long-Term Debt i1.98B35.85B
Long-Term Debt % of Revenue i45.5%80.5%
Total Shareholders Equity i2.72B53.54B
Retained Earnings i-392.00M59.16B
Retained Earnings % of Revenue i-9.0%132.8%
Property, Plant & Equipment i370.00M0

Cash Flow Statement Comparison

MetricILMN (2025)TMO (2025)
Operating Cash Flow i1.39B7.82B
Operating Cash Flow % of Revenue i32.0%17.5%
Capital Expenditures i-148.00M-1.48B
Free Cash Flow i931.00M6.29B
FCF Margin i21.4%14.1%
Debt Repayment i-500.00M-3.51B
Common Stock Repurchase i-742.00M-3.00B

Short Interest & Institutional Ownership Analysis

MetricILMNTMO
Shares Short i6.96M4.54M
Short Ratio i4.782.38
Short % of Float i7.46%1.22%
Shares Outstanding i153.00M371.62M
Float Shares i148.62M371.07M
% Held by Insiders i0.22%0.17%
% Held by Institutions i108.01%95.23%
% Held by Public i-8.23%4.60%

Dividend Analysis & Yield Comparison: Illumina, Inc. vs Thermo Fisher Scientific Inc.

MetricILMNTMO
Last 12-Month Dividend iN/A$1.76
Last 12-Month Dividend Yield iN/A0.38%
3-Year Avg Annual Dividend iN/A$1.60
3-Year Avg Dividend Yield iN/A0.08%
3-Year Total Dividends iN/A$4.80
Ex-Dividend DateN/AMar 13, 2026