Sionna Therapeutics [SION] vs Vertex [VRTX] Detailed Stock Comparison

Sionna Therapeutics Inc.

NASDAQ
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Vertex Pharmaceuticals Inc.

NASDAQ
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TLDR: Quick Comparison Summary

Based on 20 vital metrics comparison: Sionna Therapeutics Inc. wins in 2 metrics, Vertex Pharmaceuticals Inc. wins in 11 metrics, with 0 ties. Vertex Pharmaceuticals Inc. appears stronger overall.

View Metrics Details

Vital Metrics Comparison

Metric Sionna Therapeutics Inc. Vertex Pharmaceuticals Inc. Better
P/E Ratio (TTM) N/A 28.40 N/A
Price-to-Book Ratio 6.09 5.92 Vertex Pharmaceuticals Inc.
Debt-to-Equity Ratio 2.83 10.91 Sionna Therapeutics Inc.
PEG Ratio -16.19 0.88 Vertex Pharmaceuticals Inc.
EV/EBITDA -18.72 21.78 Vertex Pharmaceuticals Inc.
Profit Margin (TTM) 0.00% 32.94% Vertex Pharmaceuticals Inc.
Operating Margin (TTM) 0.00% 39.60% Vertex Pharmaceuticals Inc.
EBITDA Margin (TTM) N/A 39.60% N/A
Return on Equity -31.79% 22.54% Vertex Pharmaceuticals Inc.
Return on Assets (TTM) -21.74% 12.16% Vertex Pharmaceuticals Inc.
Free Cash Flow (TTM) $-66.67M $3.19B Vertex Pharmaceuticals Inc.
1-Year Return 212.78% 1.24% Sionna Therapeutics Inc.
Price-to-Sales Ratio (TTM) N/A 9.22 N/A
Enterprise Value $1.65B $105.96B Vertex Pharmaceuticals Inc.
EV/Revenue Ratio N/A 8.83 N/A
Gross Profit Margin (TTM) N/A 85.39% N/A
Revenue per Share (TTM) N/A $47 N/A
Earnings per Share (Diluted) $-1.88 $15.32 Vertex Pharmaceuticals Inc.
Beta (Stock Volatility) N/A 0.37 N/A
Short % of Float 13.85% 1.78% Vertex Pharmaceuticals Inc.

Sionna Therapeutics Inc. vs Vertex Pharmaceuticals Inc. Stock Performance Analysis

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SION
VRTX

Performance Comparison

Short-term Returns

Stock1D1W1M3M6MYTD
Sionna Therapeutics Inc.0.60%-15.50%-9.27%7.66%-10.84%-6.40%
Vertex Pharmaceuticals Inc.0.76%-2.03%-0.35%-9.68%-7.51%-5.26%

Long-term Returns

Stock1Y3Y5Y10Y15Y20Y
Sionna Therapeutics Inc.212.78%71.28%71.28%71.28%71.28%71.28%
Vertex Pharmaceuticals Inc.1.24%34.08%113.19%376.31%717.28%1,190.86%

Performance & Financial Health Analysis: Sionna Therapeutics Inc. vs Vertex Pharmaceuticals Inc.

MetricSIONVRTX
Market Information
Market Cap i$1.73B$109.45B
Market Cap CategorySmall capLarge cap
10 Day Avg. Volume i502,5931,057,061
90 Day Avg. Volume i387,9141,272,097
Last Close$36.70$428.34
52 Week Range$13.51 - $48.44$362.50 - $507.92
% from 52W High-24.24%-15.67%
All-Time High$48.44 (May 11, 2026)$519.88 (Nov 04, 2024)
% from All-Time High-24.24%-17.61%
Growth Metrics
Quarterly Revenue GrowthN/A0.10%
Quarterly Earnings GrowthN/A0.31%
Financial Health
Profit Margin (TTM) i0.00%0.33%
Operating Margin (TTM) i0.00%0.40%
Return on Equity (TTM) i-0.32%0.23%
Debt to Equity (MRQ) i2.8310.91
Cash & Liquidity
Book Value per Share (MRQ)$6.86$73.49
Cash per Share (MRQ)$5.24$26.01
Operating Cash Flow (TTM) i$-66,297,000$3.63B
Levered Free Cash Flow (TTM) i$-44,264,752$2.57B
Dividends
Last 12-Month Dividend Yield iN/AN/A
Last 12-Month Dividend iN/AN/A

Valuation & Enterprise Metrics Analysis: Sionna Therapeutics Inc. vs Vertex Pharmaceuticals Inc.

MetricSION (Apr 24, 2026)VRTX (Apr 26, 2026)
Price Ratios
P/E Ratio (TTM) iN/A28.40
Forward P/E i-16.1919.95
PEG Ratio i-16.190.88
Price to Sales (TTM) iN/A9.22
Price to Book (MRQ) i6.095.92
Market Capitalization
Market Capitalization i$1.73B$109.45B
Enterprise Value i$1.65B$105.96B
Enterprise Value Metrics
Enterprise to Revenue iN/A8.83
Enterprise to EBITDA i-18.7221.78
Risk & Other Metrics
Beta iN/A0.37
Book Value per Share (MRQ) i$6.86$73.49

Financial Statements Comparison: Sionna Therapeutics Inc. vs Vertex Pharmaceuticals Inc.

Financial Metrics

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Revenue

Operating Margin

Profit Margin

Long Term Debt

Income Flow Analysis

Financial Statements Comparison

Income Statement

MetricSION (2025)VRTX (2025)
Revenue/Sales i012.00B
Cost of Goods Sold iN/A1.65B
COGS % of Revenue i-13.8%
Gross Profit iN/A10.35B
Gross Margin i-86.2%
Research & Development i60.26M4.04B
Operating Income (EBIT) i-88.98M4.55B
Operating Margin i-37.9%
EBITDA i-88.34M5.25B
EBITDA Margin i-43.7%
Pre-Tax Income i-75.27M4.64B
Pre-Tax Income % of Revenue i-38.7%
Income Tax iN/A690.00M
Income Tax % of Revenue i-5.7%
Net Income (Profit) i-75.27M3.95B
Profit Margin i-32.9%

Balance Sheet & Liquidity Metrics

MetricSION (2025)VRTX (2025)
Cash & Equivalents i58.45M5.08B
Total Current Assets i241.42M11.20B
Total Current Assets % of Revenue i-93.3%
Total Current Liabilities i11.71M3.86B
Total Current Liabilities % of Revenue i-32.2%
Long-Term Debt i7.41M1.95B
Long-Term Debt % of Revenue i-16.3%
Total Shareholders Equity i306.83M18.67B
Retained Earnings i-256.35M13.56B
Retained Earnings % of Revenue i-113.0%
Property, Plant & Equipment i8.50M1.56B

Cash Flow Statement Comparison

MetricSION (2025)VRTX (2025)
Operating Cash Flow i-63.14M3.77B
Operating Cash Flow % of Revenue i-31.4%
Capital Expenditures i-377,000-437.60M
Free Cash Flow i-66.67M3.19B
FCF Margin i-26.6%
Debt Repayment iN/A-5.40M
Common Stock Repurchase iN/A-2.39B

Short Interest & Institutional Ownership Analysis

MetricSIONVRTX
Shares Short i3.76M4.02M
Short Ratio i11.902.80
Short % of Float i13.85%1.78%
Shares Outstanding i44.72M253.99M
Float Shares i15.78M253.24M
% Held by Insiders i6.87%0.21%
% Held by Institutions i97.02%97.60%
% Held by Public i-3.89%2.19%

Dividend Analysis & Yield Comparison: Sionna Therapeutics Inc. vs Vertex Pharmaceuticals Inc.

MetricSIONVRTX
Last 12-Month Dividend iN/AN/A
Last 12-Month Dividend Yield iN/AN/A
3-Year Avg Annual Dividend iN/AN/A
3-Year Avg Dividend Yield iN/AN/A
3-Year Total Dividends iN/AN/A
Ex-Dividend DateN/AN/A