Spyre Therapeutics [SYRE] vs Bio-Techne [TECH] Detailed Stock Comparison

Spyre Therapeutics Inc.

NASDAQ
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Bio-Techne Corporation

NASDAQ
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TLDR: Quick Comparison Summary

Based on 21 vital metrics comparison: Spyre Therapeutics Inc. wins in 3 metrics, Bio-Techne Corporation wins in 12 metrics, with 1 ties. Bio-Techne Corporation appears stronger overall.

View Metrics Details

Vital Metrics Comparison

Metric Spyre Therapeutics Inc. Bio-Techne Corporation Better
P/E Ratio (TTM) 1.68 117.16 Spyre Therapeutics Inc.
Price-to-Book Ratio 9.74 4.55 Bio-Techne Corporation
Debt-to-Equity Ratio 0.00 20.07 Tie
PEG Ratio -0.12 -0.82 Spyre Therapeutics Inc.
EV/EBITDA -21.22 28.87 Bio-Techne Corporation
Profit Margin (TTM) 0.00% 6.41% Bio-Techne Corporation
Operating Margin (TTM) 0.00% 14.51% Bio-Techne Corporation
EBITDA Margin (TTM) N/A 14.51% N/A
Return on Equity -25.17% 3.80% Bio-Techne Corporation
Return on Assets (TTM) -19.80% 6.09% Bio-Techne Corporation
Free Cash Flow (TTM) $-169.25M $256.55M Bio-Techne Corporation
Dividend Yield N/A 0.62% N/A
1-Year Return 381.02% 6.78% Spyre Therapeutics Inc.
Price-to-Sales Ratio (TTM) N/A 7.35 N/A
Enterprise Value $4.87B $9.19B Bio-Techne Corporation
EV/Revenue Ratio N/A 7.56 N/A
Gross Profit Margin (TTM) N/A 62.72% N/A
Revenue per Share (TTM) $0 $8 Bio-Techne Corporation
Earnings per Share (Diluted) $-1.98 $0.49 Bio-Techne Corporation
Beta (Stock Volatility) 2.94 1.47 Bio-Techne Corporation
Short % of Float 15.98% 5.09% Bio-Techne Corporation

Spyre Therapeutics Inc. vs Bio-Techne Corporation Stock Performance Analysis

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SYRE
TECH

Performance Comparison

Short-term Returns

Stock1D1W1M3M6MYTD
Spyre Therapeutics Inc.6.30%1.39%6.35%83.48%128.32%140.42%
Bio-Techne Corporation2.17%5.74%-7.11%-10.77%-20.32%-14.75%

Long-term Returns

Stock1Y3Y5Y10Y15Y20Y
Spyre Therapeutics Inc.381.02%2,196.88%-55.25%-61.32%-75.48%-75.48%
Bio-Techne Corporation6.78%-37.73%-51.28%86.91%161.27%281.12%

Performance & Financial Health Analysis: Spyre Therapeutics Inc. vs Bio-Techne Corporation

MetricSYRETECH
Market Information
Market Cap i$6.01B$9.07B
Market Cap CategoryMid capMid cap
10 Day Avg. Volume i2,018,7202,151,790
90 Day Avg. Volume i1,236,7702,370,067
Last Close$73.52$50.85
52 Week Range$13.93 - $78.80$43.20 - $72.16
% from 52W High-6.70%-29.53%
All-Time High$318.75 (Apr 04, 2016)$135.96 (Sep 20, 2021)
% from All-Time High-76.93%-62.60%
Growth Metrics
Quarterly Revenue GrowthN/A-0.01%
Quarterly Earnings GrowthN/A0.14%
Financial Health
Profit Margin (TTM) i0.00%0.06%
Operating Margin (TTM) i0.00%0.15%
Return on Equity (TTM) i-0.25%0.04%
Debt to Equity (MRQ) i0.0020.07
Cash & Liquidity
Book Value per Share (MRQ)$7.16$12.62
Cash per Share (MRQ)$9.63$0.93
Operating Cash Flow (TTM) i$-169,252,000$251.25M
Levered Free Cash Flow (TTM) i$-103,849,248$274.30M
Dividends
Last 12-Month Dividend Yield iN/A0.62%
Last 12-Month Dividend iN/A$0.40

Valuation & Enterprise Metrics Analysis: Spyre Therapeutics Inc. vs Bio-Techne Corporation

MetricSYRE (Apr 26, 2026)TECH (Nov 10, 2025)
Price Ratios
P/E Ratio (TTM) i1.68117.16
Forward P/E i-23.0626.21
PEG Ratio i-0.12-0.82
Price to Sales (TTM) iN/A7.35
Price to Book (MRQ) i9.744.55
Market Capitalization
Market Capitalization i$6.01B$9.07B
Enterprise Value i$4.87B$9.19B
Enterprise Value Metrics
Enterprise to Revenue iN/A7.56
Enterprise to EBITDA i-21.2228.87
Risk & Other Metrics
Beta i2.941.47
Book Value per Share (MRQ) i$7.16$12.62

Financial Statements Comparison: Spyre Therapeutics Inc. vs Bio-Techne Corporation

Financial Metrics

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Revenue

Operating Margin

Profit Margin

Long Term Debt

Income Flow Analysis

Financial Statements Comparison

Income Statement

MetricSYRE (2025)TECH (2025)
Revenue/Sales i01.22B
Cost of Goods Sold iN/A429.36M
COGS % of Revenue i-35.2%
Gross Profit iN/A790.27M
Gross Margin i-64.8%
Research & Development i171.65M99.50M
Operating Income (EBIT) i-219.56M242.80M
Operating Margin i-19.9%
EBITDA i-229.56M357.57M
EBITDA Margin i-29.3%
Pre-Tax Income i-155.22M98.46M
Pre-Tax Income % of Revenue i-8.1%
Income Tax i-15,00025.06M
Income Tax % of Revenue i-2.1%
Net Income (Profit) i-155.20M73.40M
Profit Margin i-6.0%

Balance Sheet & Liquidity Metrics

MetricSYRE (2025)TECH (2025)
Cash & Equivalents i85.72M162.19M
Total Current Assets i777.78M608.30M
Total Current Assets % of Revenue i-49.9%
Total Current Liabilities i58.69M175.85M
Total Current Liabilities % of Revenue i-14.4%
Long-Term Debt iN/A429.96M
Long-Term Debt % of Revenue i-35.3%
Total Shareholders Equity i715.24M1.92B
Retained Earnings i-1.13B1.07B
Retained Earnings % of Revenue i-87.4%
Property, Plant & Equipment iN/A73.40M

Cash Flow Statement Comparison

MetricSYRE (2025)TECH (2025)
Operating Cash Flow i-139.71M185.64M
Operating Cash Flow % of Revenue i-15.2%
Capital Expenditures i0-31.01M
Free Cash Flow i-169.25M256.55M
FCF Margin i-21.0%
Debt Repayment iN/A-77.00M
Common Stock Repurchase iN/A-275.73M

Short Interest & Institutional Ownership Analysis

MetricSYRETECH
Shares Short i11.67M6.94M
Short Ratio i9.412.59
Short % of Float i15.98%5.09%
Shares Outstanding i78.19M154.97M
Float Shares i69.18M153.94M
% Held by Insiders i6.09%0.28%
% Held by Institutions i97.16%102.89%
% Held by Public i-3.25%-3.17%

Dividend Analysis & Yield Comparison: Spyre Therapeutics Inc. vs Bio-Techne Corporation

MetricSYRETECH
Last 12-Month Dividend iN/A$0.40
Last 12-Month Dividend Yield iN/A0.62%
3-Year Avg Annual Dividend iN/A$0.32
3-Year Avg Dividend Yield iN/A0.12%
3-Year Total Dividends iN/A$0.96
Ex-Dividend DateN/AFeb 13, 2026