Trevi Therapeutics [TRVI] vs Vertex [VRTX] Detailed Stock Comparison

Trevi Therapeutics Inc.

NASDAQ
Loading...

Vertex Pharmaceuticals Inc.

NASDAQ
Loading...

TLDR: Quick Comparison Summary

Based on 20 vital metrics comparison: Trevi Therapeutics Inc. wins in 2 metrics, Vertex Pharmaceuticals Inc. wins in 12 metrics, with 0 ties. Vertex Pharmaceuticals Inc. appears stronger overall.

View Metrics Details

Vital Metrics Comparison

Metric Trevi Therapeutics Inc. Vertex Pharmaceuticals Inc. Better
P/E Ratio (TTM) N/A 28.40 N/A
Price-to-Book Ratio 10.09 5.92 Vertex Pharmaceuticals Inc.
Debt-to-Equity Ratio 0.41 10.91 Trevi Therapeutics Inc.
PEG Ratio -25.50 0.88 Vertex Pharmaceuticals Inc.
EV/EBITDA -33.81 21.78 Vertex Pharmaceuticals Inc.
Profit Margin (TTM) 0.00% 32.94% Vertex Pharmaceuticals Inc.
Operating Margin (TTM) 0.00% 39.60% Vertex Pharmaceuticals Inc.
EBITDA Margin (TTM) N/A 39.60% N/A
Return on Equity -30.23% 22.54% Vertex Pharmaceuticals Inc.
Return on Assets (TTM) -20.26% 12.16% Vertex Pharmaceuticals Inc.
Free Cash Flow (TTM) $-42.10M $3.19B Vertex Pharmaceuticals Inc.
1-Year Return 117.20% 1.24% Trevi Therapeutics Inc.
Price-to-Sales Ratio (TTM) N/A 9.22 N/A
Enterprise Value $1.66B $105.96B Vertex Pharmaceuticals Inc.
EV/Revenue Ratio N/A 8.83 N/A
Gross Profit Margin (TTM) N/A 85.39% N/A
Revenue per Share (TTM) N/A $47 N/A
Earnings per Share (Diluted) $-0.32 $15.32 Vertex Pharmaceuticals Inc.
Beta (Stock Volatility) 1.00 0.37 Vertex Pharmaceuticals Inc.
Short % of Float 14.10% 1.78% Vertex Pharmaceuticals Inc.

Trevi Therapeutics Inc. vs Vertex Pharmaceuticals Inc. Stock Performance Analysis

Loading Price Chart...

TRVI
VRTX

Performance Comparison

Short-term Returns

Stock1D1W1M3M6MYTD
Trevi Therapeutics Inc.-0.37%-6.92%-6.47%9.71%-1.82%13.12%
Vertex Pharmaceuticals Inc.0.76%-2.03%-0.35%-9.68%-7.51%-5.26%

Long-term Returns

Stock1Y3Y5Y10Y15Y20Y
Trevi Therapeutics Inc.117.20%531.25%570.14%70.98%70.98%70.98%
Vertex Pharmaceuticals Inc.1.24%34.08%113.19%376.31%717.28%1,190.86%

Performance & Financial Health Analysis: Trevi Therapeutics Inc. vs Vertex Pharmaceuticals Inc.

MetricTRVIVRTX
Market Information
Market Cap i$2.04B$109.45B
Market Cap CategoryMid capLarge cap
10 Day Avg. Volume i2,161,0601,057,061
90 Day Avg. Volume i1,606,9501,272,097
Last Close$13.45$428.34
52 Week Range$5.38 - $16.12$362.50 - $507.92
% from 52W High-16.56%-15.67%
All-Time High$16.12 (Apr 20, 2026)$519.88 (Nov 04, 2024)
% from All-Time High-16.56%-17.61%
Growth Metrics
Quarterly Revenue GrowthN/A0.10%
Quarterly Earnings GrowthN/A0.31%
Financial Health
Profit Margin (TTM) i0.00%0.33%
Operating Margin (TTM) i0.00%0.40%
Return on Equity (TTM) i-0.30%0.23%
Debt to Equity (MRQ) i0.4110.91
Cash & Liquidity
Book Value per Share (MRQ)$1.43$73.49
Cash per Share (MRQ)$1.47$26.01
Operating Cash Flow (TTM) i$-42,089,000$3.63B
Levered Free Cash Flow (TTM) i$-27,859,000$2.57B
Dividends
Last 12-Month Dividend Yield iN/AN/A
Last 12-Month Dividend iN/AN/A

Valuation & Enterprise Metrics Analysis: Trevi Therapeutics Inc. vs Vertex Pharmaceuticals Inc.

MetricTRVI (Apr 26, 2026)VRTX (Apr 26, 2026)
Price Ratios
P/E Ratio (TTM) iN/A28.40
Forward P/E i-25.5019.95
PEG Ratio i-25.500.88
Price to Sales (TTM) iN/A9.22
Price to Book (MRQ) i10.095.92
Market Capitalization
Market Capitalization i$2.04B$109.45B
Enterprise Value i$1.66B$105.96B
Enterprise Value Metrics
Enterprise to Revenue iN/A8.83
Enterprise to EBITDA i-33.8121.78
Risk & Other Metrics
Beta i1.000.37
Book Value per Share (MRQ) i$1.43$73.49

Financial Statements Comparison: Trevi Therapeutics Inc. vs Vertex Pharmaceuticals Inc.

Financial Metrics

Loading Financial Charts...

Revenue

Operating Margin

Profit Margin

Long Term Debt

Income Flow Analysis

Financial Statements Comparison

Income Statement

MetricTRVI (2025)VRTX (2025)
Revenue/Sales i012.00B
Cost of Goods Sold iN/A1.65B
COGS % of Revenue i-13.8%
Gross Profit iN/A10.35B
Gross Margin i-86.2%
Research & Development i33.48M4.04B
Operating Income (EBIT) i-49.33M4.55B
Operating Margin i-37.9%
EBITDA i-42.68M5.25B
EBITDA Margin i-43.7%
Pre-Tax Income i-42.82M4.64B
Pre-Tax Income % of Revenue i-38.7%
Income Tax i-64,000690.00M
Income Tax % of Revenue i-5.7%
Net Income (Profit) i-42.76M3.95B
Profit Margin i-32.9%

Balance Sheet & Liquidity Metrics

MetricTRVI (2025)VRTX (2025)
Cash & Equivalents i18.91M5.08B
Total Current Assets i191.66M11.20B
Total Current Assets % of Revenue i-93.3%
Total Current Liabilities i9.75M3.86B
Total Current Liabilities % of Revenue i-32.2%
Long-Term Debt i446,0001.95B
Long-Term Debt % of Revenue i-16.3%
Total Shareholders Equity i183.24M18.67B
Retained Earnings i-329.80M13.56B
Retained Earnings % of Revenue i-113.0%
Property, Plant & Equipment i677,0001.56B

Cash Flow Statement Comparison

MetricTRVI (2025)VRTX (2025)
Operating Cash Flow i-37.57M3.77B
Operating Cash Flow % of Revenue i-31.4%
Capital Expenditures i-12,000-437.60M
Free Cash Flow i-42.10M3.19B
FCF Margin i-26.6%
Debt Repayment i-11,000-5.40M
Common Stock Repurchase iN/A-2.39B

Short Interest & Institutional Ownership Analysis

MetricTRVIVRTX
Shares Short i16.14M4.02M
Short Ratio i12.392.80
Short % of Float i14.10%1.78%
Shares Outstanding i128.31M253.99M
Float Shares i105.98M253.24M
% Held by Insiders i0.64%0.21%
% Held by Institutions i95.98%97.60%
% Held by Public i3.38%2.19%

Dividend Analysis & Yield Comparison: Trevi Therapeutics Inc. vs Vertex Pharmaceuticals Inc.

MetricTRVIVRTX
Last 12-Month Dividend iN/AN/A
Last 12-Month Dividend Yield iN/AN/A
3-Year Avg Annual Dividend iN/AN/A
3-Year Avg Dividend Yield iN/AN/A
3-Year Total Dividends iN/AN/A
Ex-Dividend DateN/AN/A