Twist Bioscience [TWST] vs Thermo Fisher [TMO] Detailed Stock Comparison

Twist Bioscience Corporation

NASDAQ
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Thermo Fisher Scientific Inc.

NYSE
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TLDR: Quick Comparison Summary

Based on 21 vital metrics comparison: Twist Bioscience Corporation wins in 2 metrics, Thermo Fisher Scientific Inc. wins in 16 metrics, with 0 ties. Thermo Fisher Scientific Inc. appears stronger overall.

View Metrics Details

Vital Metrics Comparison

Metric Twist Bioscience Corporation Thermo Fisher Scientific Inc. Better
P/E Ratio (TTM) -45.26 25.84 Thermo Fisher Scientific Inc.
Price-to-Book Ratio 8.49 3.31 Thermo Fisher Scientific Inc.
Debt-to-Equity Ratio 24.79 82.91 Twist Bioscience Corporation
PEG Ratio 8.00 2.29 Thermo Fisher Scientific Inc.
EV/EBITDA -33.62 19.02 Thermo Fisher Scientific Inc.
Profit Margin (TTM) -19.56% 15.15% Thermo Fisher Scientific Inc.
Operating Margin (TTM) -31.73% 17.89% Thermo Fisher Scientific Inc.
EBITDA Margin (TTM) N/A 17.89% N/A
Return on Equity -16.79% 13.52% Thermo Fisher Scientific Inc.
Return on Assets (TTM) -13.49% 5.00% Thermo Fisher Scientific Inc.
Free Cash Flow (TTM) $-75.63M $6.29B Thermo Fisher Scientific Inc.
Dividend Yield N/A 0.38% N/A
1-Year Return 127.24% 16.53% Twist Bioscience Corporation
Price-to-Sales Ratio (TTM) 9.90 3.86 Thermo Fisher Scientific Inc.
Enterprise Value $3.79B $214.76B Thermo Fisher Scientific Inc.
EV/Revenue Ratio 9.68 4.75 Thermo Fisher Scientific Inc.
Gross Profit Margin (TTM) 52.05% N/A N/A
Revenue per Share (TTM) $7 $120 Thermo Fisher Scientific Inc.
Earnings per Share (Diluted) $-1.27 $18.18 Thermo Fisher Scientific Inc.
Beta (Stock Volatility) 2.21 0.97 Thermo Fisher Scientific Inc.
Short % of Float 29.74% 1.22% Thermo Fisher Scientific Inc.

Twist Bioscience Corporation vs Thermo Fisher Scientific Inc. Stock Performance Analysis

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TWST
TMO

Performance Comparison

Short-term Returns

Stock1D1W1M3M6MYTD
Twist Bioscience Corporation6.07%15.35%64.31%79.49%160.03%149.43%
Thermo Fisher Scientific Inc.0.93%0.87%8.07%0.79%-17.74%-20.05%

Long-term Returns

Stock1Y3Y5Y10Y15Y20Y
Twist Bioscience Corporation127.24%316.00%-31.53%444.07%444.07%444.07%
Thermo Fisher Scientific Inc.16.53%-12.65%-2.72%220.94%654.32%1,231.84%

Performance & Financial Health Analysis: Twist Bioscience Corporation vs Thermo Fisher Scientific Inc.

MetricTWSTTMO
Market Information
Market Cap i$3.61B$174.55B
Market Cap CategoryMid capLarge cap
10 Day Avg. Volume i1,422,1842,356,220
90 Day Avg. Volume i1,214,5612,071,517
Last Close$80.79$473.72
52 Week Range$23.30 - $82.99$385.46 - $643.99
% from 52W High-2.65%-26.44%
All-Time High$214.07 (Jan 18, 2021)$672.34 (Dec 27, 2021)
% from All-Time High-62.26%-29.54%
Growth Metrics
Quarterly Revenue Growth0.17%0.06%
Quarterly Earnings Growth0.17%0.10%
Financial Health
Profit Margin (TTM) i-0.20%0.15%
Operating Margin (TTM) i-0.32%0.18%
Return on Equity (TTM) i-0.17%0.14%
Debt to Equity (MRQ) i24.7982.91
Cash & Liquidity
Book Value per Share (MRQ)$7.44$141.96
Cash per Share (MRQ)$3.23$8.75
Operating Cash Flow (TTM) i$-51,014,000$8.29B
Levered Free Cash Flow (TTM) i$-47,241,876$5.51B
Dividends
Last 12-Month Dividend Yield iN/A0.38%
Last 12-Month Dividend iN/A$1.76

Valuation & Enterprise Metrics Analysis: Twist Bioscience Corporation vs Thermo Fisher Scientific Inc.

MetricTWST (Apr 24, 2026)TMO (Apr 26, 2026)
Price Ratios
P/E Ratio (TTM) i-45.2625.84
Forward P/E i-33.5317.16
PEG Ratio i8.002.29
Price to Sales (TTM) i9.903.86
Price to Book (MRQ) i8.493.31
Market Capitalization
Market Capitalization i$3.61B$174.55B
Enterprise Value i$3.79B$214.76B
Enterprise Value Metrics
Enterprise to Revenue i9.684.75
Enterprise to EBITDA i-33.6219.02
Risk & Other Metrics
Beta i2.210.97
Book Value per Share (MRQ) i$7.44$141.96

Financial Statements Comparison: Twist Bioscience Corporation vs Thermo Fisher Scientific Inc.

Financial Metrics

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Revenue

Operating Margin

Profit Margin

Long Term Debt

Income Flow Analysis

Financial Statements Comparison

Income Statement

MetricTWST (2025)TMO (2025)
Revenue/Sales i376.57M44.56B
Cost of Goods Sold i185.57M26.32B
COGS % of Revenue i49.3%59.1%
Gross Profit i191.00M18.24B
Gross Margin i50.7%40.9%
Research & Development i80.29M1.40B
Operating Income (EBIT) i-136.26M8.11B
Operating Margin i-36.2%18.2%
EBITDA i-160.25M11.86B
EBITDA Margin i-42.6%26.6%
Pre-Tax Income i-76.95M7.31B
Pre-Tax Income % of Revenue i-20.4%16.4%
Income Tax i719,000547.00M
Income Tax % of Revenue i0.2%1.2%
Net Income (Profit) i-77.67M6.72B
Profit Margin i-20.6%15.1%

Balance Sheet & Liquidity Metrics

MetricTWST (2025)TMO (2025)
Cash & Equivalents i183.05M9.85B
Total Current Assets i332.97M28.71B
Total Current Assets % of Revenue i88.4%64.4%
Total Current Liabilities i91.41M15.19B
Total Current Liabilities % of Revenue i24.3%34.1%
Long-Term Debt i61.75M35.85B
Long-Term Debt % of Revenue i16.4%80.5%
Total Shareholders Equity i472.96M53.54B
Retained Earnings i-1.32B59.16B
Retained Earnings % of Revenue i-350.4%132.8%
Property, Plant & Equipment i150.96M0

Cash Flow Statement Comparison

MetricTWST (2025)TMO (2025)
Operating Cash Flow i1.59M7.82B
Operating Cash Flow % of Revenue i0.4%17.5%
Capital Expenditures i-28.00M-1.48B
Free Cash Flow i-75.63M6.29B
FCF Margin i-20.1%14.1%
Debt Repayment iN/A-3.51B
Common Stock Repurchase i-16,000-3.00B

Short Interest & Institutional Ownership Analysis

MetricTWSTTMO
Shares Short i14.15M4.54M
Short Ratio i13.072.38
Short % of Float i29.74%1.22%
Shares Outstanding i61.27M371.62M
Float Shares i54.55M371.07M
% Held by Insiders i1.50%0.17%
% Held by Institutions i122.49%95.23%
% Held by Public i-23.99%4.60%

Dividend Analysis & Yield Comparison: Twist Bioscience Corporation vs Thermo Fisher Scientific Inc.

MetricTWSTTMO
Last 12-Month Dividend iN/A$1.76
Last 12-Month Dividend Yield iN/A0.38%
3-Year Avg Annual Dividend iN/A$1.60
3-Year Avg Dividend Yield iN/A0.08%
3-Year Total Dividends iN/A$4.80
Ex-Dividend DateN/AMar 13, 2026