Upstream Bio [UPB] vs Vertex [VRTX] Detailed Stock Comparison

Upstream Bio Inc.

NASDAQ
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Vertex Pharmaceuticals Inc.

NASDAQ
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TLDR: Quick Comparison Summary

Based on 20 vital metrics comparison: Upstream Bio Inc. wins in 2 metrics, Vertex Pharmaceuticals Inc. wins in 15 metrics, with 0 ties. Vertex Pharmaceuticals Inc. appears stronger overall.

View Metrics Details

Vital Metrics Comparison

Metric Upstream Bio Inc. Vertex Pharmaceuticals Inc. Better
P/E Ratio (TTM) -3.50 28.40 Vertex Pharmaceuticals Inc.
Price-to-Book Ratio 1.48 5.92 Upstream Bio Inc.
Debt-to-Equity Ratio 0.37 10.91 Upstream Bio Inc.
PEG Ratio -0.04 0.88 Vertex Pharmaceuticals Inc.
EV/EBITDA -1.04 21.78 Vertex Pharmaceuticals Inc.
Profit Margin (TTM) 0.00% 32.94% Vertex Pharmaceuticals Inc.
Operating Margin (TTM) -6,911.23% 39.60% Vertex Pharmaceuticals Inc.
EBITDA Margin (TTM) N/A 39.60% N/A
Return on Equity -35.44% 22.54% Vertex Pharmaceuticals Inc.
Return on Assets (TTM) -23.99% 12.16% Vertex Pharmaceuticals Inc.
Free Cash Flow (TTM) $-133.44M $3.19B Vertex Pharmaceuticals Inc.
1-Year Return -9.43% 1.24% Vertex Pharmaceuticals Inc.
Price-to-Sales Ratio (TTM) 177.33 9.22 Vertex Pharmaceuticals Inc.
Enterprise Value $165.87M $105.96B Vertex Pharmaceuticals Inc.
EV/Revenue Ratio 58.12 8.83 Vertex Pharmaceuticals Inc.
Gross Profit Margin (TTM) N/A 85.39% N/A
Revenue per Share (TTM) $0 $47 Vertex Pharmaceuticals Inc.
Earnings per Share (Diluted) $-2.66 $15.32 Vertex Pharmaceuticals Inc.
Beta (Stock Volatility) N/A 0.37 N/A
Short % of Float 8.56% 1.78% Vertex Pharmaceuticals Inc.

Upstream Bio Inc. vs Vertex Pharmaceuticals Inc. Stock Performance Analysis

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UPB
VRTX

Performance Comparison

Short-term Returns

Stock1D1W1M3M6MYTD
Upstream Bio Inc.5.24%-7.63%-18.05%3.67%-71.71%-71.81%
Vertex Pharmaceuticals Inc.0.76%-2.03%-0.35%-9.68%-7.51%-5.26%

Long-term Returns

Stock1Y3Y5Y10Y15Y20Y
Upstream Bio Inc.-9.43%-62.00%-62.00%-62.00%-62.00%-62.00%
Vertex Pharmaceuticals Inc.1.24%34.08%113.19%376.31%717.28%1,190.86%

Performance & Financial Health Analysis: Upstream Bio Inc. vs Vertex Pharmaceuticals Inc.

MetricUPBVRTX
Market Information
Market Cap i$506.11M$109.45B
Market Cap CategorySmall capLarge cap
10 Day Avg. Volume i595,1201,057,061
90 Day Avg. Volume i763,8601,272,097
Last Close$7.63$428.34
52 Week Range$7.18 - $33.68$362.50 - $507.92
% from 52W High-77.35%-15.67%
All-Time High$33.69 (Jan 14, 2026)$519.88 (Nov 04, 2024)
% from All-Time High-77.35%-17.61%
Growth Metrics
Quarterly Revenue Growth0.09%0.10%
Quarterly Earnings Growth0.09%0.31%
Financial Health
Profit Margin (TTM) i0.00%0.33%
Operating Margin (TTM) i-69.11%0.40%
Return on Equity (TTM) i-0.35%0.23%
Debt to Equity (MRQ) i0.3710.91
Cash & Liquidity
Book Value per Share (MRQ)$6.26$73.49
Cash per Share (MRQ)$6.28$26.01
Operating Cash Flow (TTM) i$-133,275,000$3.63B
Levered Free Cash Flow (TTM) i$-88,750,624$2.57B
Dividends
Last 12-Month Dividend Yield iN/AN/A
Last 12-Month Dividend iN/AN/A

Valuation & Enterprise Metrics Analysis: Upstream Bio Inc. vs Vertex Pharmaceuticals Inc.

MetricUPB (Apr 26, 2026)VRTX (Apr 26, 2026)
Price Ratios
P/E Ratio (TTM) i-3.5028.40
Forward P/E i-2.8819.95
PEG Ratio i-0.040.88
Price to Sales (TTM) i177.339.22
Price to Book (MRQ) i1.485.92
Market Capitalization
Market Capitalization i$506.11M$109.45B
Enterprise Value i$165.87M$105.96B
Enterprise Value Metrics
Enterprise to Revenue i58.128.83
Enterprise to EBITDA i-1.0421.78
Risk & Other Metrics
Beta iN/A0.37
Book Value per Share (MRQ) i$6.26$73.49

Financial Statements Comparison: Upstream Bio Inc. vs Vertex Pharmaceuticals Inc.

Financial Metrics

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Revenue

Operating Margin

Profit Margin

Long Term Debt

Income Flow Analysis

Financial Statements Comparison

Income Statement

MetricUPB (2025)VRTX (2025)
Revenue/Sales i2.85M12.00B
Cost of Goods Sold iN/A1.65B
COGS % of Revenue i0.0%13.8%
Gross Profit iN/A10.35B
Gross Margin i0.0%86.2%
Research & Development i136.81M4.04B
Operating Income (EBIT) i-160.36M4.55B
Operating Margin i-5,618.8%37.9%
EBITDA i-160.17M5.25B
EBITDA Margin i-5,612.2%43.7%
Pre-Tax Income i-143.44M4.64B
Pre-Tax Income % of Revenue i-5,026.0%38.7%
Income Tax iN/A690.00M
Income Tax % of Revenue i0.0%5.7%
Net Income (Profit) i-143.44M3.95B
Profit Margin i-5,026.0%32.9%

Balance Sheet & Liquidity Metrics

MetricUPB (2025)VRTX (2025)
Cash & Equivalents i101.58M5.08B
Total Current Assets i351.80M11.20B
Total Current Assets % of Revenue i12,326.5%93.3%
Total Current Liabilities i13.45M3.86B
Total Current Liabilities % of Revenue i471.3%32.2%
Long-Term Debt i549,0001.95B
Long-Term Debt % of Revenue i19.2%16.3%
Total Shareholders Equity i339.77M18.67B
Retained Earnings i-334.22M13.56B
Retained Earnings % of Revenue i-11,710.7%113.0%
Property, Plant & Equipment i1.22M1.56B

Cash Flow Statement Comparison

MetricUPB (2025)VRTX (2025)
Operating Cash Flow i-134.26M3.77B
Operating Cash Flow % of Revenue i-4,704.4%31.4%
Capital Expenditures i-165,000-437.60M
Free Cash Flow i-133.44M3.19B
FCF Margin i-4,675.5%26.6%
Debt Repayment iN/A-5.40M
Common Stock Repurchase iN/A-2.39B

Short Interest & Institutional Ownership Analysis

MetricUPBVRTX
Shares Short i3.02M4.02M
Short Ratio i3.732.80
Short % of Float i8.56%1.78%
Shares Outstanding i54.24M253.99M
Float Shares i34.59M253.24M
% Held by Insiders i14.88%0.21%
% Held by Institutions i95.64%97.60%
% Held by Public i-10.52%2.19%

Dividend Analysis & Yield Comparison: Upstream Bio Inc. vs Vertex Pharmaceuticals Inc.

MetricUPBVRTX
Last 12-Month Dividend iN/AN/A
Last 12-Month Dividend Yield iN/AN/A
3-Year Avg Annual Dividend iN/AN/A
3-Year Avg Dividend Yield iN/AN/A
3-Year Total Dividends iN/AN/A
Ex-Dividend DateN/AN/A