Urogen Pharma [URGN] vs Zymeworks [ZYME] Detailed Stock Comparison

TLDR: Quick Comparison Summary

Based on 19 vital metrics comparison: Urogen Pharma Ltd. wins in 7 metrics, Zymeworks Inc. wins in 11 metrics, with 0 ties. Zymeworks Inc. appears stronger overall.

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Vital Metrics Comparison

Metric Urogen Pharma Ltd. Zymeworks Inc. Better
P/E Ratio (TTM) -7.62 3.79 Zymeworks Inc.
Price-to-Book Ratio -11.34 7.32 Zymeworks Inc.
Debt-to-Equity Ratio -1.23 6.80 Zymeworks Inc.
PEG Ratio 0.23 0.05 Zymeworks Inc.
EV/EBITDA -9.86 -20.40 Urogen Pharma Ltd.
Profit Margin (TTM) -139.81% -76.56% Zymeworks Inc.
Operating Margin (TTM) -50.52% -1,755.55% Urogen Pharma Ltd.
Return on Equity 145.53% -26.72% Urogen Pharma Ltd.
Return on Assets (TTM) -32.10% -14.29% Zymeworks Inc.
Free Cash Flow (TTM) $-162.73M $-35.36M Zymeworks Inc.
1-Year Return 563.44% 119.86% Urogen Pharma Ltd.
Price-to-Sales Ratio (TTM) 11.10 18.46 Urogen Pharma Ltd.
Enterprise Value $1.23B $1.73B Zymeworks Inc.
EV/Revenue Ratio 11.19 16.33 Urogen Pharma Ltd.
Gross Profit Margin (TTM) 91.31% N/A N/A
Revenue per Share (TTM) $2 $1 Urogen Pharma Ltd.
Earnings per Share (Diluted) $-3.19 $-1.08 Zymeworks Inc.
Beta (Stock Volatility) 1.44 1.20 Zymeworks Inc.
Short % of Float 17.40% 8.16% Zymeworks Inc.

Urogen Pharma Ltd. vs Zymeworks Inc. Stock Performance Analysis

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Performance Comparison

Short-term Returns

Stock1D1W1M3M6MYTD
Urogen Pharma Ltd.0.17%-9.38%14.13%41.23%9.16%17.04%
Zymeworks Inc.1.00%-1.77%-9.07%-0.41%-7.13%-8.53%

Long-term Returns

Stock1Y3Y5Y10Y15Y20Y
Urogen Pharma Ltd.563.44%188.81%56.45%100.93%100.93%100.93%
Zymeworks Inc.119.86%189.85%-20.78%93.31%93.31%93.31%

Performance & Financial Health Analysis: Urogen Pharma Ltd. vs Zymeworks Inc.

MetricURGNZYME
Market Information
Market Cap i$1.18B$1.96B
Market Cap CategorySmall capSmall cap
10 Day Avg. Volume i913,553626,460
90 Day Avg. Volume i733,814729,503
Last Close$26.58$24.35
52 Week Range$4.71 - $32.37$11.51 - $29.75
% from 52W High-17.87%-18.15%
All-Time High$69.57 (May 21, 2018)$59.03 (Jan 11, 2021)
% from All-Time High-61.79%-58.75%
Growth Metrics
Quarterly Revenue Growth0.54%-0.92%
Quarterly Earnings Growth0.54%-0.92%
Financial Health
Profit Margin (TTM) i-1.40%-0.77%
Operating Margin (TTM) i-0.51%-17.56%
Return on Equity (TTM) i1.46%-0.27%
Debt to Equity (MRQ) i-1.236.80
Cash & Liquidity
Book Value per Share (MRQ)$-2.18$3.60
Cash per Share (MRQ)$2.47$3.10
Operating Cash Flow (TTM) i$-162,444,000$-33,005,000
Levered Free Cash Flow (TTM) i$-99,423,000$-12,959,125
Dividends
Last 12-Month Dividend Yield iN/AN/A
Last 12-Month Dividend iN/AN/A

Valuation & Enterprise Metrics Analysis: Urogen Pharma Ltd. vs Zymeworks Inc.

MetricURGN (Apr 24, 2026)ZYME (Apr 13, 2026)
Price Ratios
P/E Ratio (TTM) i-7.623.79
Forward P/E i24.0733.43
PEG Ratio i0.230.05
Price to Sales (TTM) i11.1018.46
Price to Book (MRQ) i-11.347.32
Market Capitalization
Market Capitalization i$1.18B$1.96B
Enterprise Value i$1.23B$1.73B
Enterprise Value Metrics
Enterprise to Revenue i11.1916.33
Enterprise to EBITDA i-9.86-20.40
Risk & Other Metrics
Beta i1.441.20
Book Value per Share (MRQ) i$-2.18$3.60

Financial Statements Comparison: Urogen Pharma Ltd. vs Zymeworks Inc.

Financial Metrics

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Revenue

Operating Margin

Profit Margin

Long Term Debt

Income Flow Analysis

Financial Statements Comparison

Income Statement

MetricURGN (2025)ZYME (2025)
Revenue/Sales i109.79M105.97M
Cost of Goods Sold i12.45MN/A
COGS % of Revenue i11.3%0.0%
Gross Profit i97.34MN/A
Gross Margin i88.7%0.0%
Research & Development i67.11M137.00M
Operating Income (EBIT) i-124.86M-92.54M
Operating Margin i-113.7%-87.3%
EBITDA i-135.66M-80.82M
EBITDA Margin i-123.6%-76.3%
Pre-Tax Income i-153.42M-79.75M
Pre-Tax Income % of Revenue i-139.7%-75.3%
Income Tax i78,0001.38M
Income Tax % of Revenue i0.1%1.3%
Net Income (Profit) i-153.49M-81.13M
Profit Margin i-139.8%-76.6%

Balance Sheet & Liquidity Metrics

MetricURGN (2025)ZYME (2025)
Cash & Equivalents i110.75M41.16M
Total Current Assets i186.02M248.77M
Total Current Assets % of Revenue i169.4%234.8%
Total Current Liabilities i46.42M42.32M
Total Current Liabilities % of Revenue i42.3%39.9%
Long-Term Debt i128.33M14.80M
Long-Term Debt % of Revenue i116.9%14.0%
Total Shareholders Equity i-105.47M268.50M
Retained Earnings i-959.72M-953.16M
Retained Earnings % of Revenue i-874.2%-899.5%
Property, Plant & Equipment i9.64M29.56M

Cash Flow Statement Comparison

MetricURGN (2025)ZYME (2025)
Operating Cash Flow i-160.55M-40.00M
Operating Cash Flow % of Revenue i-146.2%-37.7%
Capital Expenditures i-289,000-1.52M
Free Cash Flow i-162.73M-35.36M
FCF Margin i-148.2%-33.4%
Debt Repayment i-1.86MN/A
Common Stock Repurchase iN/A-41.70M

Short Interest & Institutional Ownership Analysis

MetricURGNZYME
Shares Short i8.35M4.08M
Short Ratio i9.295.42
Short % of Float i17.40%8.16%
Shares Outstanding i48.35M75.19M
Float Shares i38.66M72.80M
% Held by Insiders i3.75%1.26%
% Held by Institutions i99.35%98.45%
% Held by Public i-3.10%0.29%

Dividend Analysis & Yield Comparison: Urogen Pharma Ltd. vs Zymeworks Inc.

MetricURGNZYME
Last 12-Month Dividend iN/AN/A
Last 12-Month Dividend Yield iN/AN/A
3-Year Avg Annual Dividend iN/AN/A
3-Year Avg Dividend Yield iN/AN/A
3-Year Total Dividends iN/AN/A
Ex-Dividend DateN/AN/A