Zymeworks (ZYME) | Financial Analysis & Statements
Zymeworks Inc. Small-cap Healthcare
TL;DR: Financial Overview - Revenue, Profits & Key Metrics
Latest Quarterly: Dec 2025Income Metrics
Revenue
2.5M
Operating Income
-44.1M
-1,754.27%
Net Income
-41.2M
-1,638.53%
Balance Sheet Metrics
Total Assets
346.5M
Total Liabilities
78.0M
Shareholders Equity
268.5M
Debt to Equity
0.29
Cash Flow Metrics
Operating Cash Flow
-4.5M
Free Cash Flow
-11.0M
Revenue & Profitability Trend
Quarter Income Flow
Dec 31, 2025
Annual Income Flow
2025
Zymeworks Income Statement From 2021 to 2025
| Metric | 2025 | 2024 | 2023 | 2022 | 2021 |
|---|---|---|---|---|---|
| Revenue | 106.0M | 76.3M | 76.0M | 412.5M | 18.4M |
| Cost of Goods Sold | - | - | - | - | - |
| Gross Profit | - | - | - | - | - |
| Gross Margin % | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Operating Expenses | |||||
| Research & Development | 137.0M | 134.6M | 143.6M | 208.6M | 137.4M |
| Selling, General & Administrative | 61.5M | 61.5M | 70.4M | 73.4M | 29.3M |
| Other Operating Expenses | - | - | - | - | - |
| Total Operating Expenses | 198.5M | 196.1M | 214.0M | 282.0M | 166.7M |
| Operating Income | -92.5M | -119.8M | -138.0M | 130.5M | -148.4M |
| Operating Margin % | -87.3% | -157.0% | -181.6% | 31.6% | -808.4% |
| Non-Operating Items | |||||
| Interest Income | 13.4M | 19.9M | 19.7M | 3.6M | 1.4M |
| Interest Expense | - | - | - | - | - |
| Other Non-Operating Income | -559.0K | -16.7M | -894.0K | 1.1M | 900.6K |
| Pre-tax Income | -79.8M | -116.6M | -119.2M | 135.2M | -146.1M |
| Income Tax | 1.4M | 6.1M | -568.0K | 10.9M | -355.0K |
| Effective Tax Rate % | 0.0% | 0.0% | 0.0% | 8.1% | 0.0% |
| Net Income | -81.1M | -122.7M | -118.7M | 124.3M | -145.8M |
| Net Margin % | -76.6% | -160.8% | -156.1% | 30.1% | -794.0% |
| Key Metrics | |||||
| EBITDA | -80.8M | -92.1M | -119.5M | 141.3M | -142.6M |
| EPS (Basic) | $-1.08 | $-1.62 | $-1.72 | $1.91 | $-4.11 |
| EPS (Diluted) | $-1.08 | $-1.62 | $-1.72 | $1.90 | $-4.61 |
| Basic Shares Outstanding | 75404897 | 75846681 | 68863010 | 65194775 | 51553869 |
| Diluted Shares Outstanding | 75404897 | 75846681 | 68863010 | 65194775 | 51553869 |
Income Statement Trend
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Zymeworks Balance Sheet From 2021 to 2025
| Metric | 2025 | 2024 | 2023 | 2022 | 2021 |
|---|---|---|---|---|---|
| Assets | |||||
| Current Assets | |||||
| Cash & Equivalents | 41.2M | 66.1M | 157.6M | 400.9M | 138.9M |
| Short-term Investments | 187.6M | 159.7M | 216.8M | 91.3M | 34.9M |
| Accounts Receivable | 4.6M | 55.8M | 19.5M | 33.4M | 10.7M |
| Inventory | - | - | - | - | - |
| Other Current Assets | 15.3M | 18.9M | 19.1M | 19.1M | 20.0M |
| Total Current Assets | 248.8M | 300.5M | 412.9M | 544.7M | 198.3M |
| Non-Current Assets | |||||
| Property, Plant & Equipment | 29.6M | 30.0M | 29.5M | 32.6M | 24.3M |
| Goodwill | 25.4M | 28.6M | 49.3M | 50.4M | 31.3M |
| Intangible Assets | 1.4M | 4.6M | 25.3M | 26.4M | 14.8M |
| Long-term Investments | - | - | - | - | - |
| Other Non-Current Assets | 11.4M | 13.3M | 3.7M | 1.4M | 2.9M |
| Total Non-Current Assets | 97.8M | 162.6M | 168.0M | 104.0M | 69.4M |
| Total Assets | 346.5M | 463.1M | 580.9M | 648.7M | 267.7M |
| Liabilities | |||||
| Current Liabilities | |||||
| Accounts Payable | 4.4M | 3.9M | 6.2M | 7.9M | 3.6M |
| Short-term Debt | 3.5M | 2.7M | 4.3M | 3.3M | 901.3K |
| Current Portion of Long-term Debt | - | - | - | - | - |
| Other Current Liabilities | 844.0K | 1.3M | 2.5M | 1.6M | 5.3M |
| Total Current Liabilities | 42.3M | 88.3M | 55.8M | 95.6M | 49.4M |
| Non-Current Liabilities | |||||
| Long-term Debt | 14.8M | 15.8M | 22.5M | 24.8M | 21.3M |
| Deferred Tax Liabilities | 6.0M | 4.8M | 3.3M | 1.8M | 1.1M |
| Other Non-Current Liabilities | 278.0K | 895.0K | 1.6M | 3.0M | 1.8M |
| Total Non-Current Liabilities | 35.7M | 36.0M | 60.3M | 60.1M | 46.9M |
| Total Liabilities | 78.0M | 124.3M | 116.1M | 155.8M | 96.3M |
| Equity | |||||
| Common Stock | 1.1B | 1.0B | 1.0B | 906.8M | 509.9M |
| Retained Earnings | -953.2M | -830.3M | -677.4M | -558.8M | -470.0M |
| Treasury Stock | - | - | - | - | - |
| Other Equity | - | - | - | - | - |
| Total Shareholders Equity | 268.5M | 338.8M | 464.8M | 493.0M | 171.4M |
| Key Metrics | |||||
| Total Debt | 18.3M | 18.5M | 26.7M | 28.1M | 22.2M |
| Working Capital | 206.4M | 212.2M | 357.2M | 449.1M | 148.9M |
Balance Sheet Composition
Zymeworks Cash Flow Statement From 2021 to 2025
| Metric | 2025 | 2024 | 2023 | 2022 | 2021 |
|---|---|---|---|---|---|
| Operating Activities | |||||
| Net Income | -81.1M | -122.7M | -118.7M | 124.3M | -145.8M |
| Depreciation & Amortization | 11.1M | 11.2M | 17.3M | 12.0M | 6.6M |
| Stock-Based Compensation | 28.0M | 17.8M | 8.1M | 4.0M | 7.4M |
| Working Capital Changes | 1.0M | -26.8M | -30.8M | 5.2M | 11.1M |
| Operating Cash Flow | -40.0M | -121.7M | -124.2M | 147.3M | -121.1M |
| Investing Activities | |||||
| Capital Expenditures | -1.5M | -2.0M | -2.5M | -8.2M | -8.5M |
| Acquisitions | - | - | - | - | - |
| Investment Purchases | -196.1M | -283.7M | -553.2M | -113.0M | -24.1M |
| Investment Sales | 225.1M | 325.6M | 350.1M | 72.3M | 132.8M |
| Investing Cash Flow | 27.5M | 39.8M | -205.6M | -48.9M | 100.1M |
| Financing Activities | |||||
| Share Repurchases | -41.7M | -30.1M | - | - | - |
| Dividends Paid | - | - | - | - | - |
| Debt Issuance | - | - | - | - | - |
| Debt Repayment | - | -14.0K | -21.0K | -14.0K | -11.7K |
| Financing Cash Flow | -36.9M | -30.2M | 76.0M | 106.9M | -335.1K |
| Free Cash Flow | -35.4M | -113.1M | -122.4M | 131.0M | -141.6M |
| Net Change in Cash | -49.4M | -112.1M | -253.8M | 205.3M | -21.4M |
Cash Flow Trend
Zymeworks Key Financial Ratios
Valuation Ratios
P/E Ratio (TTM)
3.79
Forward P/E
33.43
Price to Book
7.32
Price to Sales
18.46
PEG Ratio
0.05
Profitability Ratios
Profit Margin
-76.56%
Operating Margin
-1,755.55%
Return on Equity
-26.72%
Return on Assets
-14.29%
Financial Health
Current Ratio
5.88
Debt to Equity
6.80
Beta
1.20
Per Share Data
EPS (TTM)
$-1.08
Book Value per Share
$3.60
Revenue per Share
$1.41
Peer Financial Comparison
| Company | Market Cap | P/E Ratio | P/B Ratio | ROE | Profit Margin | Debt/Equity |
|---|---|---|---|---|---|---|
| ZYME | 2.0B | 3.79 | 7.32 | -26.72% | -76.56% | 6.80 |
| Vertex | 109.4B | 28.40 | 5.92 | 22.54% | 32.94% | 10.91 |
| Regeneron | 81.0B | 18.00 | 2.45 | 14.86% | 31.41% | 9.51 |
| Adaptive | 2.1B | -35.44 | 9.99 | -27.82% | -21.48% | 93.49 |
| Agios | 1.5B | 3.82 | 1.26 | -30.20% | 88.26% | 3.37 |
| Ocular Therapeutix | 2.1B | -6.67 | 3.13 | -54.85% | 87.35% | 11.76 |
Financial data is updated regularly. All figures are in the company's reporting currency.






