Madrigal [MDGL] vs Ionis [IONS] Detailed Stock Comparison
Madrigal
NASDAQ
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Ionis
NASDAQ
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TLDR: Quick Comparison Summary
Based on 19 vital metrics comparison: Madrigal wins in 7 metrics, Ionis wins in 11 metrics, with 0 ties. Ionis appears stronger overall.
View Metrics Details
Vital Metrics Comparison
| Metric | Madrigal | Ionis | Better |
|---|---|---|---|
| P/E Ratio (TTM) | -19.77 | -20.09 | Ionis |
| Price-to-Book Ratio | 13.82 | 15.43 | Madrigal |
| Debt-to-Equity Ratio | 17.81 | 314.06 | Madrigal |
| PEG Ratio | 0.27 | 0.07 | Ionis |
| EV/EBITDA | -29.10 | -37.04 | Ionis |
| Profit Margin (TTM) | -54.68% | -28.41% | Ionis |
| Operating Margin (TTM) | -22.18% | 30.93% | Ionis |
| EBITDA Margin (TTM) | N/A | 30.93% | N/A |
| Return on Equity | -36.30% | -59.91% | Madrigal |
| Return on Assets (TTM) | -18.31% | -5.87% | Ionis |
| Free Cash Flow (TTM) | $-462.03M | $-551.29M | Madrigal |
| 1-Year Return | 87.68% | 44.58% | Madrigal |
| Price-to-Sales Ratio (TTM) | 18.72 | 10.34 | Ionis |
| Enterprise Value | $8.98B | $9.45B | Ionis |
| EV/Revenue Ratio | 17.41 | 10.01 | Ionis |
| Gross Profit Margin (TTM) | 95.74% | 99.08% | Ionis |
| Revenue per Share (TTM) | $23 | $6 | Madrigal |
| Earnings per Share (Diluted) | $-12.63 | $-1.76 | Ionis |
| Beta (Stock Volatility) | -1.03 | 0.28 | Madrigal |
Performance
News Sentiment
Key Stats
Valuation
Financials
Short Interest
Dividends
Madrigal vs Ionis Stock Performance Analysis
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Performance Comparison
Short-term Returns
| Stock | 1D | 1W | 1M | 3M | 6M | YTD |
|---|---|---|---|---|---|---|
| Madrigal | -1.10% | 4.06% | 31.26% | 61.93% | 37.87% | 44.62% |
| Ionis | 5.60% | 6.11% | 46.49% | 65.94% | 89.32% | 75.84% |
Long-term Returns
| Stock | 1Y | 3Y | 5Y | 10Y | 15Y | 20Y |
|---|---|---|---|---|---|---|
| Madrigal | 87.68% | 554.74% | 269.30% | 511.59% | 246.68% | 31.63% |
| Ionis | 44.58% | 31.66% | 18.70% | 11.80% | 638.50% | 1,053.12% |
News Based Sentiment: Madrigal vs Ionis
Madrigal
News based Sentiment: POSITIVE
September was a strong month for Madrigal Pharmaceuticals, driven by a significant earnings beat, a soaring stock price reaching an all-time high, and positive analyst coverage. The planned expansion into the German market with Rezdiffra further strengthens the company's long-term growth prospects, making it a pivotal month for investors.
Ionis
News based Sentiment: POSITIVE
September 2025 was a pivotal month for Ionis Pharmaceuticals, marked by a major FDA approval, a significant earnings beat, and highly promising Phase 3 trial results for a key drug candidate. These events collectively signal a transition from a research-focused biotech to a commercial-stage pharmaceutical company with substantial growth potential, making it a highly significant month for investors.
Performance & Financial Health Analysis: Madrigal vs Ionis
| Metric | MDGL | IONS |
|---|---|---|
| Market Information | ||
| Market Cap | $9.65B | $9.95B |
| Market Cap Category | Mid cap | Mid cap |
| 10 Day Avg. Volume | 346,592 | 4,404,577 |
| 90 Day Avg. Volume | 423,031 | 2,912,509 |
| Last Close | $448.79 | $64.42 |
| 52 Week Range | $200.63 - $457.16 | $23.95 - $64.71 |
| % from 52W High | -1.83% | -0.45% |
| All-Time High | $457.16 (Sep 08, 2025) | $86.58 (Apr 08, 2019) |
| % from All-Time High | -1.83% | -25.59% |
| Growth Metrics | ||
| Quarterly Revenue Growth | 13.54% | 1.01% |
| Quarterly Earnings Growth | 13.54% | N/A |
| Financial Health | ||
| Profit Margin (TTM) | -0.55% | -0.28% |
| Operating Margin (TTM) | -0.22% | 0.31% |
| Return on Equity (TTM) | -0.36% | -0.60% |
| Debt to Equity (MRQ) | 17.81 | 314.06 |
| Cash & Liquidity | ||
| Book Value per Share (MRQ) | $31.32 | $3.97 |
| Cash per Share (MRQ) | $35.76 | $14.39 |
| Operating Cash Flow (TTM) | $-307,412,992 | $-230,566,000 |
| Levered Free Cash Flow (TTM) | $-219,782,000 | $-168,629,872 |
| Dividends | ||
| Last 12-Month Dividend Yield | N/A | N/A |
| Last 12-Month Dividend | N/A | N/A |
Valuation & Enterprise Metrics Analysis: Madrigal vs Ionis
| Metric | MDGL | IONS |
|---|---|---|
| Price Ratios | ||
| P/E Ratio (TTM) | -19.77 | -20.09 |
| Forward P/E | -31.01 | -16.37 |
| PEG Ratio | 0.27 | 0.07 |
| Price to Sales (TTM) | 18.72 | 10.34 |
| Price to Book (MRQ) | 13.82 | 15.43 |
| Market Capitalization | ||
| Market Capitalization | $9.65B | $9.95B |
| Enterprise Value | $8.98B | $9.45B |
| Enterprise Value Metrics | ||
| Enterprise to Revenue | 17.41 | 10.01 |
| Enterprise to EBITDA | -29.10 | -37.04 |
| Risk & Other Metrics | ||
| Beta | -1.03 | 0.28 |
| Book Value per Share (MRQ) | $31.32 | $3.97 |
Financial Statements Comparison: Madrigal vs Ionis
Financial Metrics
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Revenue
EBITDA
Operating Margin
Free Cash Flow
Long Term Debt
Profit Margin
Current Ratio
Operating Cash Flow
Income Statement (MRQ)
| Metric (MRQ) | MDGL | IONS |
|---|---|---|
| Revenue/Sales | $137.25M | $452.05M |
| Cost of Goods Sold | $4.51M | $4.15M |
| Gross Profit | $132.74M | $447.90M |
| Research & Development | $44.17M | $217.46M |
| Operating Income (EBIT) | $-79.31M | $139.84M |
| EBITDA | $-69.56M | $143.86M |
| Pre-Tax Income | $-73.24M | $123.53M |
| Income Tax | N/A | $-20,000 |
| Net Income (Profit) | $-73.24M | $123.55M |
Balance Sheet & Liquidity Metrics (MRQ)
| Metric (MRQ) | MDGL | IONS |
|---|---|---|
| Cash & Equivalents | $183.65M | $297.30M |
| Total Current Assets | $987.98M | $2.58B |
| Total Current Liabilities | $167.24M | $897.24M |
| Long-Term Debt | $118.76M | $789.87M |
| Total Shareholders Equity | $710.64M | $631.72M |
| Retained Earnings | $-1.88B | $-2.27B |
| Property, Plant & Equipment | $4.01M | $275.88M |
Cash Flow Statement Comparison (MRQ)
| Metric (MRQ) | MDGL | IONS |
|---|---|---|
| Operating Cash Flow | $-81.76M | $115.11M |
| Capital Expenditures | $0 | $-12.31M |
| Free Cash Flow | $-88.89M | $137.07M |
| Debt Repayment | N/A | $-40,000 |
| Common Stock Repurchase | N/A | N/A |
Short Interest & Institutional Ownership Analysis
| Metric | MDGL | IONS |
|---|---|---|
| Shares Short | 3.79M | 10.79M |
| Short Ratio | 8.45 | 5.47 |
| Short % of Float | 0.20% | 0.09% |
| Average Daily Volume (10 Day) | 346,592 | 4,404,577 |
| Average Daily Volume (90 Day) | 423,031 | 2,912,509 |
| Shares Outstanding | 22.00M | 157.91M |
| Float Shares | 10.98M | 157.97M |
| % Held by Insiders | 0.08% | 0.01% |
| % Held by Institutions | 1.08% | 1.08% |
Dividend Analysis & Yield Comparison: Madrigal vs Ionis
| Metric | MDGL | IONS |
|---|---|---|
| Last 12-Month Dividend | N/A | N/A |
| Last 12-Month Dividend Yield | N/A | N/A |
| 3-Year Avg Annual Dividend | N/A | N/A |
| 3-Year Avg Dividend Yield | N/A | N/A |
| 3-Year Total Dividends | N/A | N/A |
| Ex-Dividend Date | N/A | N/A |