Ionis (IONS) | Stock Overview & Key Data
Ionis Performance Comparison
Stock Range
Today's Range
52 Week Range
All-Time High: $86.74 on February 5, 2026
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Key Statistics
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Financial Highlights
Quarter Income Flow
Dec 31, 2025
Annual Income Flow
2025
Peer Performance Comparison
| Company | Market Cap | 1W | 1M | 3M | 6M | YTD | 1Y | 3Y | 5Y | 10Y | 15Y | 20Y |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ionis
IONS
|
12.24B Large-cap | -4.08% | -3.29% | -10.97% | -10.26% | -8.41% | 128.29% | 83.23% | 121.48% | 233.19% | 770.31% | 937.99% |
|
Vertex
VRTX
|
109.45B Large-cap | -2.49% | -1.11% | -12.54% | -1.86% | -5.98% | 1.24% | 34.08% | 113.19% | 376.31% | 717.28% | 1,190.86% |
|
Regeneron
REGN
|
80.98B Large-cap | -5.03% | -15.02% | -23.79% | -18.77% | -22.36% | 25.39% | -16.92% | 20.10% | 53.41% | 959.24% | 4,557.42% |
|
Alnylam
ALNY
|
41.87B Large-cap | -3.17% | -3.96% | -11.98% | -38.46% | -28.50% | -0.85% | 55.93% | 107.40% | 330.17% | 2,975.15% | 1,859.64% |
|
Insmed
INSM
|
31.05B Large-cap | -4.72% | -25.91% | -29.11% | -49.79% | -41.44% | 53.32% | 447.13% | 322.07% | 796.14% | 920.13% | 585.32% |
|
Revolution Medicines
RVMD
|
28.61B Large-cap | -2.32% | 2.30% | 48.89% | 100.90% | 91.47% | 299.70% | 515.88% | 416.50% | 456.27% | 456.27% | 456.27% |
Ownership & Short Interest
Calculate Your Ionis Investment Returns
Long-Term Investment Performance Analysis
Ionis stock price in May 2016 was $22.96, A $1,000.00 lump sum investment in Ionis made 10 years ago would be worth approximately $3,213.41 today, representing a outstanding return of 221.34%. This translates to an annualized return (CAGR) of 12.37%.
10 Years Investment Scenario (May 2016 - Jun 2026)
Investment Breakdown
Value Comparison
Disclaimer: This calculator is for informational purposes only and does not consider taxes, fees, or other costs associated with investing. Past performance does not guarantee future results.
Frequently Asked Questions
- What is IONS's 52-week high and low?
- In the last 52 weeks, Ionis reached a high of $86.74 (on February 5, 2026) and a low of $33.95 (on N/A).
- What is the market cap and P/E ratio for IONS?
- Curious about Ionis's size and valuation? Its market capitalization stands at 12.24B. When it comes to valuation, the P/E ratio (trailing twelve months) is -31.14, and the forward P/E (looking ahead) is -121.81.
- Does IONS pay dividends? If so, what's the yield?
- As for dividends, Ionis isn't currently offering a significant yield, or that specific data isn't available right now.
- Who are Ionis's main competitors or similar companies to consider before investing?
When looking at Ionis, it can be helpful to see how it compares to other players in its field. Here are a few similar companies or key competitors:
Company Mkt Cap Sector Industry 1Y Return 3Y Return Vertex
VRTX109.45B Healthcare Biotechnology 1.24% 34.08% Regeneron
REGN80.98B Healthcare Biotechnology 25.39% -16.92% Alnylam
ALNY41.87B Healthcare Biotechnology -0.85% 55.93% Insmed
INSM31.05B Healthcare Biotechnology 53.32% 447.13% Revolution Medicines
RVMD28.61B Healthcare Biotechnology 299.70% 515.88% For a more comprehensive list, please see the Peer Performance Comparison table on this page.
- What are the key financial health indicators for Ionis Pharmaceuticals Inc.? (e.g., ROE, Debt/Equity)
- To get a sense of Ionis's financial health, here are a few key indicators: its Return on Equity (ROE) over the last twelve months is -70.80%, the Debt to Equity ratio from the most recent quarter is 534.84, and its Gross Profit Margin stands at 96.09%.
- What is the recent revenue and earnings growth for IONS?
- Looking at Ionis's growth, its revenue over the trailing twelve months (TTM) was $944M. Compared to the same quarter last year (YoY), quarterly revenue grew by -10.30%, and quarterly earnings saw a YoY growth of N/A.
- How much of IONS stock is held by insiders and institutions?
- Wondering who owns Ionis stock? Company insiders (like executives and directors) hold about 0.72% of the shares, while institutional investors (such as mutual funds and pension funds) own approximately 105.85%.
For more common questions about our data, please visit our About Data page.
Data is provided for informational purposes only. Devyara does not guarantee the accuracy of the data displayed.