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Spyre Therapeutics vs VertexSpyre Therapeutics vs RegeneronSpyre Therapeutics vs Praxis PrecisionSpyre Therapeutics vs Axsome TherapeuticsSpyre Therapeutics vs Bio-TechneSpyre Therapeutics vs S&P 500 | Market

TL;DR: Financial Overview - Revenue, Profits & Key Metrics

Latest Quarterly: Dec 2025

Income Metrics

Revenue 0
Operating Income -57.2M
Net Income -62.5M
EPS (Diluted) $-0.70

Balance Sheet Metrics

Total Assets 777.8M
Total Liabilities 62.5M
Shareholders Equity 715.2M
Debt to Equity 0.09

Cash Flow Metrics

Operating Cash Flow -39.4M
Free Cash Flow -44.6M

Revenue & Profitability Trend

Spyre Therapeutics Income Statement From 2021 to 2025

Metric 2025 2024 2023 2022 2021
Revenue i 0 0 886.0K 2.3M 18.7M
Cost of Goods Sold i - - - - -
Gross Profit i - - - - -
Gross Margin % i 0.0% 0.0% 0.0% 0.0% 0.0%
Operating Expenses
Research & Development i 171.7M 162.8M 89.5M 58.6M 57.1M
Selling, General & Administrative i 47.9M 45.8M 39.9M 28.5M 27.3M
Other Operating Expenses i - - - - -
Total Operating Expenses i 219.6M 208.6M 129.4M 87.1M 84.4M
Operating Income i -219.6M -208.6M -128.6M -84.8M -65.6M
Operating Margin % i 0.0% 0.0% -14,510.6% -3,640.2% -350.3%
Non-Operating Items
Interest Income i 24.9M 21.3M 6.1M 837.0K 111.0K
Interest Expense i - - - - -
Other Non-Operating Income 39.5M -20.7M -216.4M -7.0K -122.0K
Pre-tax Income i -155.2M -208.0M -338.8M -84.0M -65.7M
Income Tax i -15.0K 51.0K -26.0K -136.0K 141.0K
Effective Tax Rate % i 0.0% 0.0% 0.0% 0.0% 0.0%
Net Income i -155.2M -208.0M -338.8M -83.8M -65.8M
Net Margin % i 0.0% 0.0% -38,238.1% -3,598.8% -351.1%
Key Metrics
EBITDA i -229.6M -208.6M 69.4M -83.2M -64.1M
EPS (Basic) i $-1.98 $-3.18 $-13.76 $-24.75 $-25.00
EPS (Diluted) i $-1.98 $-3.18 $-13.76 $-24.75 $-25.00
Basic Shares Outstanding i 64056442 47027638 7340307 3371231 2629784
Diluted Shares Outstanding i 64056442 47027638 7340307 3371231 2629784

Income Statement Trend

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Spyre Therapeutics Balance Sheet From 2021 to 2025

Metric 2025 2024 2023 2022 2021
Assets
Current Assets
Cash & Equivalents i 85.7M 89.4M 188.9M 34.9M 15.1M
Short-term Investments i 670.8M 513.7M 150.4M 20.8M 78.0M
Accounts Receivable i - - - - -
Inventory i - - - - -
Other Current Assets 21.2M 5.4M 2.3M 6.2M 4.9M
Total Current Assets i 777.8M 608.5M 341.5M 62.3M 98.9M
Non-Current Assets
Property, Plant & Equipment i - - 0 5.7M 6.1M
Goodwill i - - - - -
Intangible Assets i - - - - -
Long-term Investments - - - - -
Other Non-Current Assets - 10.0K 331.0K 2.2M 2.7M
Total Non-Current Assets i 0 10.0K 331.0K 8.9M 11.0M
Total Assets i 777.8M 608.5M 341.9M 71.1M 109.9M
Liabilities
Current Liabilities
Accounts Payable i 8.9M 666.0K 896.0K 677.0K 3.3M
Short-term Debt i - - - 625.0K 436.0K
Current Portion of Long-term Debt - - - - -
Other Current Liabilities 23.0M 25.6M 1.9M 330.0K 783.0K
Total Current Liabilities i 58.7M 54.1M 32.0M 14.7M 20.1M
Non-Current Liabilities
Long-term Debt i - - 0 4.0M 4.6M
Deferred Tax Liabilities i - - - - -
Other Non-Current Liabilities 3.9M 36.6M 41.3M - -
Total Non-Current Liabilities i 3.9M 36.6M 125.9M 6.2M 5.8M
Total Liabilities i 62.5M 90.7M 157.8M 20.8M 26.0M
Equity
Common Stock i 15.0K 13.0K 10.0K 6.0K 5.0K
Retained Earnings i -1.1B -972.4M -764.4M -425.6M -341.8M
Treasury Stock i - - - - -
Other Equity - - - - -
Total Shareholders Equity i 715.2M 517.8M 184.0M 50.3M 83.9M
Key Metrics
Total Debt i 0 0 0 4.6M 5.1M
Working Capital i 719.1M 554.4M 309.6M 47.6M 78.7M

Balance Sheet Composition

Spyre Therapeutics Cash Flow Statement From 2021 to 2025

Metric 2025 2024 2023 2022 2021
Operating Activities
Net Income i -155.2M -208.0M -338.8M -83.8M -65.8M
Depreciation & Amortization i 0 0 744.0K 1.6M 1.6M
Stock-Based Compensation i 37.6M 44.8M 25.7M 7.1M 8.0M
Working Capital Changes i 7.6M -16.2M -1.2M -3.5M 3.4M
Operating Cash Flow i -139.7M -159.0M -310.8M -77.8M -52.7M
Investing Activities
Capital Expenditures i 0 0 475.0K -38.0K -573.0K
Acquisitions i 0 0 3.0M 0 0
Investment Purchases i -522.2M -599.3M -166.8M -39.5M -133.1M
Investment Sales i 371.7M 246.0M 39.9M 96.5M 111.0M
Investing Cash Flow i -150.5M -353.3M -123.4M 57.0M -22.6M
Financing Activities
Share Repurchases i - - - - -
Dividends Paid i - - - - -
Debt Issuance i - - - - -
Debt Repayment i - 0 -16.0K -418.0K -510.0K
Financing Cash Flow i 305.7M 403.4M 360.7M 42.5M -510.0K
Free Cash Flow i -169.3M -157.4M -99.9M -80.2M -54.3M
Net Change in Cash i 15.5M -108.9M -73.5M 21.6M -75.8M

Cash Flow Trend

Spyre Therapeutics Key Financial Ratios

Valuation Ratios

P/E Ratio (TTM) 1.68
Forward P/E -23.06
Price to Book 9.74
PEG Ratio -0.12

Profitability Ratios

Profit Margin 0.00%
Operating Margin 0.00%
Return on Equity -25.17%
Return on Assets -19.80%

Financial Health

Current Ratio 13.25
Debt to Equity 0.00
Beta 2.94

Per Share Data

EPS (TTM) $-1.98
Book Value per Share $7.16
Revenue per Share $0.00

Peer Financial Comparison

Company Market Cap P/E Ratio P/B Ratio ROE Profit Margin Debt/Equity
SYRE 6.0B 1.68 9.74 -25.17% 0.00% 0.00
Vertex 109.4B 28.40 5.92 22.54% 32.94% 10.91
Regeneron 81.0B 18.00 2.45 14.86% 31.41% 9.51
Praxis Precision 9.6B - 9.46 -45.83% 0.00% 0.01
Axsome Therapeutics 9.5B -50.54 105.31 -252.12% -28.69% 247.03
Bio-Techne 9.1B 117.16 4.55 3.80% 6.41% 20.07
Nippun Rana

Nippun Rana

Chasing the market trend!

Hi, I’m Nippun, a tech enthusiast from Haryana, India. I have been coding since 2010 and using my coding skills in the share market since 2020. I have been coding scripts in Pinescript that work on Tradingview app/web. I love learning about new technology and applying it to solve real-world problems. Coding and share-market are my passions, and I enjoy finding and fixing bugs in code. I aim to share my skill set and experience that can positively impact society. Feel free to connect with me, an...

Financial data is updated regularly. All figures are in the company's reporting currency.