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Upstream Bio (UPB) | Financial Analysis & Statements

Upstream Bio Inc. | Small-cap | Healthcare

$17.57

-1.95%

Upstream Bio vs Vertex Upstream Bio vs Alnylam Upstream Bio vs Adaptive Upstream Bio vs Dyne Therapeutics Upstream Bio vs Harmony Biosciences Upstream Bio vs S&P 500 | Market

TL;DR Income Statement Balance Sheet Cash Flow Key Ratios Peer Comparison

TL;DR: Financial Overview - Revenue, Profits & Key Metrics

Latest Quarterly: Mar 2025

Income Metrics

Revenue 566.0K

Operating Income -32.0M -5,656.01%

Net Income -27.3M -4,818.02%

EPS (Diluted) $-0.51

Balance Sheet Metrics

Total Assets 456.2M

Total Liabilities 10.6M

Shareholders Equity 445.6M

Debt to Equity 0.02

Cash Flow Metrics

Operating Cash Flow -23.8M

Free Cash Flow -41.2M

Revenue & Profitability Trend

Interactive Financial Charts Not Available

This page uses interactive financial charts and dynamic data visualization tools that require JavaScript. For detailed financial analysis:

Available Financial Data:

Income statements (annual and quarterly)
Balance sheets with asset and liability details
Cash flow statements and free cash flow analysis
Key financial ratios and performance metrics
Peer comparison and industry benchmarking

All financial data is displayed in accessible table format below. Use the table headers and structure to analyze trends and compare metrics across different periods.

Upstream Bio Income Statement From 2022 to 2024

Metric	2024	2023	2022
Revenue i	2.4M	2.4M	1.2M
Cost of Goods Sold i	-	-	-
Gross Profit i	-	-	-
Gross Margin % i	0.0%	0.0%	0.0%
Operating Expenses
Research & Development i	63.0M	31.8M	18.7M
Selling, General & Administrative i	17.2M	10.7M	6.5M
Other Operating Expenses i	-	-	-
Total Operating Expenses i	80.1M	42.5M	25.1M
Operating Income i	-77.8M	-40.1M	-23.9M
Operating Margin % i	-3,281.2%	-1,685.5%	-1,972.7%
Non-Operating Items
Interest Income i	12.1M	4.2M	205.0K
Interest Expense i	-	-	-
Other Non-Operating Income	2.8M	15.4M	-164.0K
Pre-tax Income i	-62.8M	-20.5M	-23.9M
Income Tax i	-	-	-
Effective Tax Rate % i	0.0%	0.0%	0.0%
Net Income i	-62.8M	-20.5M	-23.9M
Net Margin % i	-2,650.0%	-862.9%	-1,969.3%
Key Metrics
EBITDA i	-77.7M	-40.1M	-23.9M
EPS (Basic) i	$-5.58	$-1.05	$-0.66
EPS (Diluted) i	$-5.58	$-1.05	$-0.66
Basic Shares Outstanding i	13682326	36323322	36323322
Diluted Shares Outstanding i	13682326	36323322	36323322

Income Statement Trend

Upstream Bio Balance Sheet From 2022 to 2024

Metric	2024	2023	2022
Assets
Current Assets
Cash & Equivalents i	325.9M	25.8M	17.1M
Short-term Investments i	144.6M	84.0M	0
Accounts Receivable i	613.0K	98.0K	412.0K
Inventory i	-	-	-
Other Current Assets	494.0K	370.0K	233.0K
Total Current Assets i	479.2M	117.0M	18.3M
Non-Current Assets
Property, Plant & Equipment i	1.8M	43.0K	89.0K
Goodwill i	-	-	-
Intangible Assets i	-	-	-
Long-term Investments	-	-	-
Other Non-Current Assets	194.0K	-	7.0K
Total Non-Current Assets i	2.6M	202.0K	171.0K
Total Assets i	481.7M	117.2M	18.5M
Liabilities
Current Liabilities
Accounts Payable i	4.0M	2.0M	712.0K
Short-term Debt i	704.0K	45.0K	87.0K
Current Portion of Long-term Debt	-	-	-
Other Current Liabilities	-	-	-
Total Current Liabilities i	10.7M	6.5M	4.9M
Non-Current Liabilities
Long-term Debt i	1.1M	0	7.0K
Deferred Tax Liabilities i	-	-	-
Other Non-Current Liabilities	-	-	-
Total Non-Current Liabilities i	1.1M	233.8M	119.8M
Total Liabilities i	11.9M	240.3M	124.6M
Equity
Common Stock i	53.0K	3.0K	3.0K
Retained Earnings i	-190.8M	-128.0M	-107.4M
Treasury Stock i	-	-	-
Other Equity	-	-	-
Total Shareholders Equity i	469.9M	-123.1M	-106.2M
Key Metrics
Total Debt i	1.8M	45.0K	94.0K
Working Capital i	468.4M	110.5M	13.5M

Balance Sheet Composition

Upstream Bio Cash Flow Statement From 2022 to 2024

Metric	2024	2023	2022
Operating Activities
Net Income i	-62.8M	-20.5M	-23.9M
Depreciation & Amortization i	89.0K	60.0K	7.0K
Stock-Based Compensation i	6.0M	3.4M	1.3M
Working Capital Changes i	1.4M	1.5M	-24.0K
Operating Cash Flow i	-58.0M	-30.9M	-22.5M
Investing Activities
Capital Expenditures i	-511.0K	-144.0K	-82.0K
Acquisitions i	-	-	-
Investment Purchases i	-290.6M	-129.0M	0
Investment Sales i	231.6M	46.3M	0
Investing Cash Flow i	-59.5M	-82.8M	-82.0K
Financing Activities
Share Repurchases i	-	-	-
Dividends Paid i	-	-	-
Debt Issuance i	-	-	-
Debt Repayment i	-	-	-
Financing Cash Flow i	418.8M	129.4M	10.0M
Free Cash Flow i	-59.7M	-38.1M	-19.1M
Net Change in Cash i	301.2M	15.7M	-12.6M

Cash Flow Trend

Upstream Bio Key Financial Ratios

Valuation Ratios

P/E Ratio (TTM) -3.15

Forward P/E -7.41

Price to Book 2.31

Price to Sales 347.85

PEG Ratio -7.41

Profitability Ratios

Profit Margin 0.00%

Operating Margin -4,732.87%

Return on Equity -32.49%

Return on Assets -22.85%

Financial Health

Current Ratio 38.27

Debt to Equity 0.38

Per Share Data

EPS (TTM) $-6.18

Book Value per Share $7.60

Revenue per Share $0.07

Peer Financial Comparison

Company	Market Cap	P/E Ratio	P/B Ratio	ROE	Profit Margin	Debt/Equity
upb	947.2M	-3.15	2.31	-32.49%	0.00%	0.38
Vertex	101.2B	28.08	5.89	22.77%	31.86%	8.89
Alnylam	61.1B	-213.71	244.95	-257.83%	-12.96%	1,093.31
Adaptive	1.9B	-11.68	10.68	-57.60%	-59.07%	121.39
Dyne Therapeutics	1.9B	-3.90	2.63	-61.32%	0.00%	21.19
Harmony Biosciences	1.9B	10.45	2.41	27.58%	23.42%	22.43

Financial data is updated regularly. All figures are in the company's reporting currency.