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Upstream Bio vs VertexUpstream Bio vs RegeneronUpstream Bio vs CapricorUpstream Bio vs ZymeworksUpstream Bio vs AmylyxUpstream Bio vs S&P 500 | Market

TL;DR: Financial Overview - Revenue, Profits & Key Metrics

Latest Quarterly: Dec 2025

Income Metrics

Revenue 668.0K
Operating Income -46.2M -6,911.23%
Net Income -42.5M -6,356.14%

Balance Sheet Metrics

Total Assets 353.8M
Total Liabilities 14.0M
Shareholders Equity 339.8M
Debt to Equity 0.04

Cash Flow Metrics

Operating Cash Flow -41.1M
Free Cash Flow -30.7M

Revenue & Profitability Trend

Quarter Income Flow i

Annual Income Flow i

Upstream Bio Income Statement From 2022 to 2025

Metric 2025 2024 2023 2022
Revenue i 2.9M 2.4M 2.4M 1.2M
Cost of Goods Sold i - - - -
Gross Profit i - - - -
Gross Margin % i 0.0% 0.0% 0.0% 0.0%
Operating Expenses
Research & Development i 136.8M 63.0M 31.8M 18.7M
Selling, General & Administrative i 26.4M 17.2M 10.7M 6.5M
Other Operating Expenses i - - - -
Total Operating Expenses i 163.2M 80.1M 42.5M 25.1M
Operating Income i -160.4M -77.8M -40.1M -23.9M
Operating Margin % i -5,618.8% -3,281.2% -1,685.5% -1,972.7%
Non-Operating Items
Interest Income i 16.9M 12.1M 4.2M 205.0K
Interest Expense i - - - -
Other Non-Operating Income -15.0K 2.8M 15.4M -164.0K
Pre-tax Income i -143.4M -62.8M -20.5M -23.9M
Income Tax i - - - -
Effective Tax Rate % i 0.0% 0.0% 0.0% 0.0%
Net Income i -143.4M -62.8M -20.5M -23.9M
Net Margin % i -5,026.0% -2,650.0% -862.9% -1,969.3%
Key Metrics
EBITDA i -160.2M -77.7M -40.1M -23.9M
EPS (Basic) i $-2.66 $-1.17 $-1.05 $-0.66
EPS (Diluted) i $-2.66 $-1.17 $-1.05 $-0.66
Basic Shares Outstanding i 53852752 53603398 36323322 36323322
Diluted Shares Outstanding i 53852752 53603398 36323322 36323322

Income Statement Trend

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Upstream Bio Balance Sheet From 2022 to 2025

Metric 2025 2024 2023 2022
Assets
Current Assets
Cash & Equivalents i 101.6M 325.9M 25.8M 17.1M
Short-term Investments i 239.9M 144.6M 84.0M 0
Accounts Receivable i 668.0K 613.0K 98.0K 412.0K
Inventory i - - - -
Other Current Assets 727.0K 494.0K 370.0K 233.0K
Total Current Assets i 351.8M 479.2M 117.0M 18.3M
Non-Current Assets
Property, Plant & Equipment i 1.2M 1.8M 43.0K 89.0K
Goodwill i - - - -
Intangible Assets i - - - -
Long-term Investments - - - -
Other Non-Current Assets 194.0K 194.0K - 7.0K
Total Non-Current Assets i 2.0M 2.6M 202.0K 171.0K
Total Assets i 353.8M 481.7M 117.2M 18.5M
Liabilities
Current Liabilities
Accounts Payable i 2.7M 4.0M 2.0M 712.0K
Short-term Debt i 720.0K 704.0K 45.0K 87.0K
Current Portion of Long-term Debt - - - -
Other Current Liabilities - - - -
Total Current Liabilities i 13.5M 10.7M 6.5M 4.9M
Non-Current Liabilities
Long-term Debt i 549.0K 1.1M 0 7.0K
Deferred Tax Liabilities i - - - -
Other Non-Current Liabilities - - - -
Total Non-Current Liabilities i 549.0K 1.1M 233.8M 119.8M
Total Liabilities i 14.0M 11.9M 240.3M 124.6M
Equity
Common Stock i 54.0K 53.0K 3.0K 3.0K
Retained Earnings i -334.2M -190.8M -128.0M -107.4M
Treasury Stock i - - - -
Other Equity - - - -
Total Shareholders Equity i 339.8M 469.9M -123.1M -106.2M
Key Metrics
Total Debt i 1.3M 1.8M 45.0K 94.0K
Working Capital i 338.3M 468.4M 110.5M 13.5M

Balance Sheet Composition

Upstream Bio Cash Flow Statement From 2022 to 2025

Metric 2025 2024 2023 2022
Operating Activities
Net Income i -143.4M -62.8M -20.5M -23.9M
Depreciation & Amortization i 188.0K 89.0K 60.0K 7.0K
Stock-Based Compensation i 10.3M 6.0M 3.4M 1.3M
Working Capital Changes i -1.9M 1.4M 1.5M -24.0K
Operating Cash Flow i -134.3M -58.0M -30.9M -22.5M
Investing Activities
Capital Expenditures i -165.0K -511.0K -144.0K -82.0K
Acquisitions i - - - -
Investment Purchases i -385.9M -290.6M -129.0M 0
Investment Sales i 292.6M 231.6M 46.3M 0
Investing Cash Flow i -93.5M -59.5M -82.8M -82.0K
Financing Activities
Share Repurchases i - - - -
Dividends Paid i - - - -
Debt Issuance i - - - -
Debt Repayment i - - - -
Financing Cash Flow i -34.0K 418.8M 129.4M 10.0M
Free Cash Flow i -133.4M -59.7M -38.1M -19.1M
Net Change in Cash i -227.8M 301.2M 15.7M -12.6M

Cash Flow Trend

Upstream Bio Key Financial Ratios

Valuation Ratios

P/E Ratio (TTM) -3.50
Forward P/E -2.88
Price to Book 1.48
Price to Sales 177.33
PEG Ratio -0.04

Profitability Ratios

Profit Margin 0.00%
Operating Margin -6,911.23%
Return on Equity -35.44%
Return on Assets -23.99%

Financial Health

Current Ratio 26.15
Debt to Equity 0.37

Per Share Data

EPS (TTM) $-2.66
Book Value per Share $6.26
Revenue per Share $0.05

Peer Financial Comparison

Company Market Cap P/E Ratio P/B Ratio ROE Profit Margin Debt/Equity
UPB 506.1M -3.50 1.48 -35.44% 0.00% 0.37
Vertex 109.4B 28.40 5.92 22.54% 32.94% 10.91
Regeneron 81.0B 18.00 2.45 14.86% 31.41% 9.51
Capricor 2.0B -15.61 6.62 -46.56% 0.00% 4.75
Zymeworks 2.0B 3.79 7.32 -26.72% -76.56% 6.80
Amylyx 1.9B 2.54 6.31 -61.59% 0.00% 1.95
Nippun Rana

Nippun Rana

Chasing the market trend!

Hi, I’m Nippun, a tech enthusiast from Haryana, India. I have been coding since 2010 and using my coding skills in the share market since 2020. I have been coding scripts in Pinescript that work on Tradingview app/web. I love learning about new technology and applying it to solve real-world problems. Coding and share-market are my passions, and I enjoy finding and fixing bugs in code. I aim to share my skill set and experience that can positively impact society. Feel free to connect with me, an...

Financial data is updated regularly. All figures are in the company's reporting currency.