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Ionis vs VertexIonis vs RegeneronIonis vs AlnylamIonis vs InsmedIonis vs Revolution MedicinesIonis vs S&P 500 | Market

TL;DR: Financial Overview - Revenue, Profits & Key Metrics

Latest Quarterly: Dec 2025

Income Metrics

Revenue 203.3M
Gross Profit 195.4M 96.09%
Operating Income -214.5M -105.48%
Net Income -229.4M -112.82%

Balance Sheet Metrics

Total Assets 3.5B
Total Liabilities 3.0B
Shareholders Equity 489.1M
Debt to Equity 6.20

Cash Flow Metrics

Operating Cash Flow -126.0M
Free Cash Flow -160.4M

Revenue & Profitability Trend

Quarter Income Flow i

Annual Income Flow i

Ionis Income Statement From 2021 to 2025

Metric 2025 2024 2023 2022 2021
Revenue i 943.7M 705.1M 787.6M 587.4M 810.5M
Cost of Goods Sold i 15.9M 11.2M 9.1M 14.1M 10.8M
Gross Profit i 927.8M 693.9M 778.5M 573.3M 799.6M
Gross Margin % i 98.3% 98.4% 98.8% 97.6% 98.7%
Operating Expenses
Research & Development i 915.6M 901.5M 899.6M 833.1M 643.5M
Selling, General & Administrative i 393.9M 267.5M 232.6M 150.3M 170.9M
Other Operating Expenses i - - - - -
Total Operating Expenses i 1.3B 1.2B 1.1B 983.4M 814.4M
Operating Income i -381.7M -475.1M -353.7M -410.2M -14.7M
Operating Margin % i -40.4% -67.4% -44.9% -69.8% -1.8%
Non-Operating Items
Interest Income i - - - - -
Interest Expense i 83.8M 84.4M 75.6M 2.8M 4.4M
Other Non-Operating Income 92.1M 105.5M 101.2M 160.3M -5.0M
Pre-tax Income i -379.6M -460.1M -334.0M -258.0M -29.1M
Income Tax i 1.8M -6.2M 32.3M 11.7M -551.0K
Effective Tax Rate % i 0.0% 0.0% 0.0% 0.0% 0.0%
Net Income i -381.4M -453.9M -366.3M -269.7M -28.6M
Net Margin % i -40.4% -64.4% -46.5% -45.9% -3.5%
Key Metrics
EBITDA i -381.1M -457.8M -322.8M -400.7M -9.9M
EPS (Basic) i $-2.38 $-3.04 $-2.56 $-1.90 $-0.20
EPS (Diluted) i $-2.38 $-3.04 $-2.56 $-1.90 $-0.20
Basic Shares Outstanding i 160010000 150000000 143000000 142000000 141000000
Diluted Shares Outstanding i 160010000 150000000 143000000 142000000 141000000

Income Statement Trend

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Ionis Balance Sheet From 2021 to 2025

Metric 2025 2024 2023 2022 2021
Assets
Current Assets
Cash & Equivalents i 372.3M 242.1M 399.3M 276.5M 869.2M
Short-term Investments i 2.3B 2.1B 1.9B 1.7B 1.2B
Accounts Receivable i - - - - -
Inventory i 10.0M 12.5M 28.4M 22.0M 24.8M
Other Current Assets 237.1M 217.9M 184.4M 168.3M 143.4M
Total Current Assets i 3.0B 2.6B 2.6B 2.2B 2.3B
Non-Current Assets
Property, Plant & Equipment i 238.5M 161.9M 171.9M 181.5M 18.0M
Goodwill i - - - - 29.0M
Intangible Assets i - - - - 29.0M
Long-term Investments - - - - -
Other Non-Current Assets 171.6M 127.3M 105.3M 75.3M 70.6M
Total Non-Current Assets i 533.2M 383.4M 348.2M 331.2M 266.6M
Total Assets i 3.5B 3.0B 3.0B 2.5B 2.6B
Liabilities
Current Liabilities
Accounts Payable i 28.1M 43.0M 26.0M 17.9M 11.9M
Short-term Debt i 454.7M 9.3M 53.2M 7.5M 3.5M
Current Portion of Long-term Debt - - - - -
Other Current Liabilities - - - - 3.5M
Total Current Liabilities i 781.6M 309.3M 448.1M 311.6M 240.6M
Non-Current Liabilities
Long-term Debt i 1.6B 1.4B 1.4B 1.4B 1.2B
Deferred Tax Liabilities i - - - - -
Other Non-Current Liabilities 551.4M 542.2M 513.7M - 26.4M
Total Non-Current Liabilities i 2.3B 2.1B 2.2B 1.6B 1.6B
Total Liabilities i 3.0B 2.4B 2.6B 2.0B 1.8B
Equity
Common Stock i 163.0K 158.0K 144.0K 142.0K 141.0K
Retained Earnings i -2.6B -2.2B -1.8B -1.4B -1.2B
Treasury Stock i - - - - -
Other Equity - - - - -
Total Shareholders Equity i 489.1M 588.4M 386.7M 572.9M 771.7M
Key Metrics
Total Debt i 2.1B 1.4B 1.5B 1.4B 1.3B
Working Capital i 2.2B 2.3B 2.2B 1.9B 2.1B

Balance Sheet Composition

Ionis Cash Flow Statement From 2021 to 2025

Metric 2025 2024 2023 2022 2021
Operating Activities
Net Income i -381.4M -453.9M -366.3M -269.7M -28.6M
Depreciation & Amortization i 22.7M 22.0M 22.5M 22.1M 19.6M
Stock-Based Compensation i 133.9M 130.2M 105.8M 100.3M 120.7M
Working Capital Changes i -103.2M -168.3M -90.3M -49.5M -78.5M
Operating Cash Flow i -300.9M -435.4M -298.3M -191.5M 38.1M
Investing Activities
Capital Expenditures i -51.4M -45.3M -23.8M -15.7M -12.0M
Acquisitions i - - - - -
Investment Purchases i -1.9B -1.9B -1.8B -1.5B -1.1B
Investment Sales i 1.7B 1.8B 1.6B 989.2M 1.3B
Investing Cash Flow i -272.1M -129.0M -209.9M -258.3M 200.9M
Financing Activities
Share Repurchases i - - - 0 0
Dividends Paid i - - - - -
Debt Issuance i 770.0M 0 575.0M 0 632.5M
Debt Repayment i -267.8M -44.7M -488.1M -50.7M -318.9M
Financing Cash Flow i 675.8M 433.6M 644.1M -55.3M 156.2M
Free Cash Flow i -325.7M -551.3M -335.5M -294.5M 12.9M
Net Change in Cash i 102.8M -130.8M 135.8M -505.0M 395.1M

Cash Flow Trend

Ionis Key Financial Ratios

Valuation Ratios

P/E Ratio (TTM) -31.14
Forward P/E -121.81
Price to Book 24.97
Price to Sales 13.09
PEG Ratio -0.27

Profitability Ratios

Profit Margin -40.41%
Operating Margin -105.47%
Return on Equity -70.80%
Return on Assets -7.31%

Financial Health

Current Ratio 3.83
Debt to Equity 534.84
Beta 0.40

Per Share Data

EPS (TTM) $-2.38
Book Value per Share $3.00
Revenue per Share $5.90

Peer Financial Comparison

Company Market Cap P/E Ratio P/B Ratio ROE Profit Margin Debt/Equity
IONS 12.2B -31.14 24.97 -70.80% -40.41% 534.84
Vertex 109.4B 28.40 5.92 22.54% 32.94% 10.91
Regeneron 81.0B 18.00 2.45 14.86% 31.41% 9.51
Alnylam 41.9B 132.73 52.09 73.28% 8.45% 376.19
Insmed 31.0B -22.40 40.88 -249.28% -210.54% 101.43
Revolution Medicines 28.6B -22.73 16.24 -58.07% 0.00% 26.19
Nippun Rana

Nippun Rana

Chasing the market trend!

Hi, I’m Nippun, a tech enthusiast from Haryana, India. I have been coding since 2010 and using my coding skills in the share market since 2020. I have been coding scripts in Pinescript that work on Tradingview app/web. I love learning about new technology and applying it to solve real-world problems. Coding and share-market are my passions, and I enjoy finding and fixing bugs in code. I aim to share my skill set and experience that can positively impact society. Feel free to connect with me, an...

Financial data is updated regularly. All figures are in the company's reporting currency.