Upstream Bio (UPB) | Stock Overview & Key Data
Upstream Bio Performance Comparison
Stock Range
Today's Range
Low: $17.54
High: $18.11
on September 12, 2025
52 Week Range
Low: $5.14
High: $29.46
on April 9, 2025
on November 6, 2024
All-Time High: $29.46 on November 4, 2024
Explore how other US stocks compare to their 52-week ranges: View US Market 52-Week Insights
Key Statistics
Market Cap
$947.2M
EPS
-6.18
P/E Ratio (TTM)
-3.15
Forward P/E
-7.41
P/B Ratio
2.31
PEG Ratio
-7.41
Div. Yield
N/A
ROE
-32.49%
Beta
N/A
Debt to Equity
0.38
Financial Highlights
Profitability
Gross Margin
N/A
Operating Margin
-4,732.87%
Profit Margin
0.00%
Returns and Earnings
Return on Assets (TTM)
-22.85%
Return on Equity (TTM)
-32.49%
EBITDA
$-121.4M
Net Income (TTM)
$-110.1M
Growth
Revenue (TTM)
Revenue Per Share (TTM)
$0.05
Quarterly Revenue Growth (YoY)
83.70%
Quarterly Earnings Growth (YoY)
83.73%
Peer Performance Comparison
| Company | Market Cap | 1W | 1M | 3M | 6M | YTD | 1Y | 3Y | 5Y |
|---|---|---|---|---|---|---|---|---|---|
| Upstream Bio UPB | 947.19M Small-cap | -12.02% | 0.40% | 51.99% | 90.36% | 7.79% | -20.14% | -20.14% | -20.14% |
| Vertex VRTX | 101.15B Large-cap | -0.40% | 1.74% | -14.24% | -20.36% | -2.77% | -18.72% | 36.18% | 48.66% |
| Alnylam ALNY | 61.07B Large-cap | 3.07% | 8.36% | 52.92% | 92.18% | 99.42% | 75.61% | 118.70% | 252.21% |
| Adaptive ADPT | 1.92B Small-cap | -1.87% | -0.39% | 21.13% | 65.49% | 103.72% | 173.54% | 65.27% | -72.79% |
| Dyne Therapeutics DYN | 1.87B Small-cap | -7.52% | 13.17% | -9.06% | 6.39% | -48.35% | -61.39% | -3.66% | -42.32% |
| Harmony Biosciences HRMY | 1.86B Small-cap | -10.00% | -8.68% | -2.82% | -3.60% | -7.01% | -16.76% | -26.12% | -3.60% |
Ownership & Short Interest
Insider Ownership
14.81%
Institutional Ownership
90.42%
Shares Short
3M
Short Ratio
6.78
Short % of Shares Outstanding
10.38%
Average 10-Day Volume
668K
Average 90-Day Volume
514K
Recurring Investment / Dollar-Cost Averaging Calculator
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Frequently Asked Questions
- What is UPB's 52-week high and low?
- In the last 52 weeks, Upstream Bio reached a high of $29.46 (on November 6, 2024) and a low of $5.14 (on April 9, 2025).
- What is the market cap and P/E ratio for UPB?
- Curious about Upstream Bio's size and valuation? Its market capitalization stands at 947.19M. When it comes to valuation, the P/E ratio (trailing twelve months) is -3.15, and the forward P/E (looking ahead) is -7.41.
- Does UPB pay dividends? If so, what's the yield?
- As for dividends, Upstream Bio isn't currently offering a significant yield, or that specific data isn't available right now.
- Who are Upstream Bio's main competitors or similar companies to consider before investing?
When looking at Upstream Bio, it can be helpful to see how it compares to other players in its field. Here are a few similar companies or key competitors:
Company Mkt Cap Sector Industry 1Y Return 3Y Return Vertex
VRTX101.15B Healthcare Biotechnology -18.72% 36.18% Alnylam
ALNY61.07B Healthcare Biotechnology 75.61% 118.70% Adaptive
ADPT1.92B Healthcare Biotechnology 173.54% 65.27% Dyne Therapeutics
DYN1.87B Healthcare Biotechnology -61.39% -3.66% Harmony Biosciences
HRMY1.86B Healthcare Biotechnology -16.76% -26.12% For a more comprehensive list, please see the Peer Performance Comparison table on this page.
- What are the key financial health indicators for Upstream Bio Inc.? (e.g., ROE, Debt/Equity)
- To get a sense of Upstream Bio's financial health, here are a few key indicators: its Return on Equity (ROE) over the last twelve months is -32.49%, the Debt to Equity ratio from the most recent quarter is 0.38, and its Gross Profit Margin stands at N/A.
- What is the recent revenue and earnings growth for UPB?
- Looking at Upstream Bio's growth, its revenue over the trailing twelve months (TTM) was $3M. Compared to the same quarter last year (YoY), quarterly revenue grew by 83.70%, and quarterly earnings saw a YoY growth of 83.73%.
- How much of UPB stock is held by insiders and institutions?
- Wondering who owns Upstream Bio stock? Company insiders (like executives and directors) hold about 14.81% of the shares, while institutional investors (such as mutual funds and pension funds) own approximately 90.42%.
For more common questions about our data, please visit our About Data page.
Data is provided for informational purposes only. Devyara does not guarantee the accuracy of the data displayed.